Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Mycophenolate mofetil versus cyclophosphamide for induction treatment of lupus nephritis
Journal of the American Society of Nephrology, Volume 20, No. 5, Year 2009
Notification
URL copied to clipboard!
Description
Recent studies have suggested that mycophenolate mofetil (MMF) may offer advantages over intravenous cyclophosphamide (IVC) for the treatment of lupus nephritis, but these therapies have not been compared in an international randomized, controlled trial. Here, we report the comparison of MMF and IVC as induction treatment for active lupus nephritis in a multinational, two-phase (induction and maintenance) study. We randomly assigned 370 patients with classes III through V lupus nephritis to open-label MMF (target dosage 3 g/d) or IVC (0.5 to 1.0 g/m2 in monthly pulses) in a 24-wk induction study. Both groups received prednisone, tapered from a maximum starting dosage of 60 mg/d. The primary end point was a prespecified decrease in urine protein/creatinine ratio and stabilization or improvement in serum creatinine. Secondary end points included complete renal remission, systemic disease activity and damage, and safety. Overall, we did not detect a significantly different response rate between the two groups: 104 (56.2%) of 185 patients responded to MMF compared with 98 (53.0%) of 185 to IVC. Secondary end points were also similar between treatment groups. There were nine deaths in the MMF group and five in the IVC group. We did not detect significant differences between the MMF and IVC groups with regard to rates of adverse events, serious adverse events, or infections. Although most patients in both treatment groups experienced clinical improvement, the study did not meet its primary objective of showing that MMF was superior to IVC as induction treatment for lupus nephritis. Copyright © 2009 by the American Society of Nephrology.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC2678035/bin/ASN.2008101028_index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC2678035/bin/ASN.2008101028_JASN-2008-10-1028-R2_Suppl-table1.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC2678035/bin/ASN.2008101028_JASN-2008-10-1028-R2_Suppl-table2.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC2678035/bin/ASN.2008101028_JASN-2008-10-1028-R2_Suppl_Fig_1.eps
https://efashare.b-cdn.net/share/pmc/articles/PMC2678035/bin/ASN.2008101028_JASN-2008-10-1028-R2_Suppl_Fig_2.eps
https://efashare.b-cdn.net/share/pmc/articles/PMC2678035/bin/ASN.2008101028v2_index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC2678035/bin/ASN.2008101028v2_1.pdf
Authors & Co-Authors
Appel, Gerald B.
Unknown Affiliation
Contreras, Gabriel
Unknown Affiliation
Dooley, Mary Anne
Unknown Affiliation
Ginzler, Ellen
Unknown Affiliation
Isenberg, David A.
Unknown Affiliation
Jayne, David R.W.
Unknown Affiliation
Li, Lei Shi
Unknown Affiliation
Mysler, Eduardo
Unknown Affiliation
Sanchez-Guerrero, Jorge
Unknown Affiliation
Solomons, Neil
Unknown Affiliation
Wofsy, David
Unknown Affiliation
Abud, Carlos
Unknown Affiliation
Adler, Sharon G.
Unknown Affiliation
Alarcón, Graciela S.
Unknown Affiliation
Albuquerque, Elisa
Unknown Affiliation
Almeida, Fernando
Unknown Affiliation
Alvarellos, Alejandro J.
Unknown Affiliation
Appel, Gerald
Unknown Affiliation
Avila, Hilario
Unknown Affiliation
Blume, Cornelia
Unknown Affiliation
Boletis, Ioannis N.
Unknown Affiliation
Bonnardeaux, Alain
Unknown Affiliation
Braun, Alan
Unknown Affiliation
Buyon, Jill P.
Unknown Affiliation
Cervera, Ricard
Unknown Affiliation
Chen, Nan
Unknown Affiliation
Chen, Shunle
Unknown Affiliation
Da Costa, António Gomes
Unknown Affiliation
Davids, Mogamat Razeen
Unknown Affiliation
D'Cruz, David P.
Unknown Affiliation
de Rámon, Enrique
Unknown Affiliation
Deodhar, Atul
Unknown Affiliation
Doria, Andrea
Unknown Affiliation
Dussol, Bertrand M.
Unknown Affiliation
Emery, Paul D.
Unknown Affiliation
Fiechtner, Justus
Unknown Affiliation
Floege, Jürgen
Unknown Affiliation
Fragoso-Loyo, Hilda
Unknown Affiliation
Furie, Richard
Unknown Affiliation
Ghazalli, Rozina
Unknown Affiliation
Ghossein, Cybele
Unknown Affiliation
Gilkeson, G. S.
Unknown Affiliation
Ginzler, Ellen
Unknown Affiliation
Gordon, Caroline
Unknown Affiliation
Grossman, Jennifer
Unknown Affiliation
Gu, Jieruo
Unknown Affiliation
Guillevin, Loïc I.
Unknown Affiliation
Hatron, Pierre Yves
Unknown Affiliation
Herrera, Gisela
Unknown Affiliation
Hiepe, Falk
Unknown Affiliation
Houssiau, Frédéric A.
Unknown Affiliation
Hübscher, Osvaldo
Unknown Affiliation
Hura, Claudia
Unknown Affiliation
Kaplan, Joshua
Unknown Affiliation
Kirsztajn, Gianna
Unknown Affiliation
Kiss, Emese
Unknown Affiliation
Kutty, Ghazali Ahmad
Unknown Affiliation
Laville, M.
Unknown Affiliation
Lazaro, Maria
Unknown Affiliation
Lenz, Oliver
Unknown Affiliation
Li, Leishi
Unknown Affiliation
Lightstone, Liz
Unknown Affiliation
Lim, Sam
Unknown Affiliation
Malaise, Michel G.
Unknown Affiliation
Manzi, Susan M.
Unknown Affiliation
Marcos, Juan Carlos
Unknown Affiliation
Meyer, Oliver C.
Unknown Affiliation
Monge, Pablo
Unknown Affiliation
Naicker, Saraladev
Unknown Affiliation
Neal, Nathaniel
Unknown Affiliation
Neuwelt, Michael
Unknown Affiliation
Nicholls, Kathleen M.
Unknown Affiliation
Olsen, Nancy
Unknown Affiliation
Ordi Ros, Josep
Unknown Affiliation
Ostrov, Barbara
Unknown Affiliation
Pestana, Manuel
Unknown Affiliation
Petri, Michelle
Unknown Affiliation
Pokorny, Gyula
Unknown Affiliation
Pourrat, Jacques P.
Unknown Affiliation
Qian, Jiaqi
Unknown Affiliation
Radhakrishnan, Jai
Unknown Affiliation
Rovin, Brad Harris
Unknown Affiliation
Sánchez-Román, Julio
Unknown Affiliation
Shanahan, Joseph
Unknown Affiliation
Shergy, William Julius
Unknown Affiliation
Skopouli, Fotini Nikolaos
Unknown Affiliation
Spindler, Alberto
Unknown Affiliation
Striebich, Christopher
Unknown Affiliation
Sundel, Robert
Unknown Affiliation
Swanepoel, Charles R.
Unknown Affiliation
Si, Yen Tan
Unknown Affiliation
Tate, Guillermo Alberto
Unknown Affiliation
Tesarˇ, Vladimír
Unknown Affiliation
Tikly, Mohammed
Unknown Affiliation
Wang, Hai Yan
Unknown Affiliation
Yahya, Rosnawati
Unknown Affiliation
Yu, Xueqing
Unknown Affiliation
Zhang, Fengchun
Unknown Affiliation
Zoruba, Diana
Unknown Affiliation
Statistics
Citations: 919
Authors: 99
Affiliations: 96
Identifiers
Doi:
10.1681/ASN.2008101028
ISSN:
10466673