Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Reciprocal effects of systemic inflammation and brain natriuretic peptide on adiponectin biosynthesis in adipose tissue of patients with ischemic heart disease
Arteriosclerosis, Thrombosis, and Vascular Biology, Volume 34, No. 9, Year 2014
Notification
URL copied to clipboard!
Description
OBJECTIVE - To explore the role of systemic inflammation in the regulation of adiponectin levels in patients with ischemic heart disease. APPROACH AND RESULTS - In a cross-sectional study of 575 subjects, serum adiponectin was compared between healthy subjects, patients with coronary artery disease with no/mild/severe heart failure (HF), and patients with nonischemic HF. Adiponectin expression and release from femoral, subcutaneous and thoracic adipose tissue was determined in 258 additional patients with coronary artery bypass grafting. Responsiveness of the various human adipose tissue depots to interleukin-6, tumor necrosis factor-α, and brain natriuretic peptide (BNP) was examined by using ex vivo models of human fat. The effects of inducible low-grade inflammation were tested by using the model of Salmonella typhi vaccine-induced inflammation in healthy individuals. In the cross-sectional study, HF strikingly increased adiponectin levels. Plasma BNP was the strongest predictor of circulating adiponectin and its release from all adipose tissue depots in patients with coronary artery bypass grafting, even in the absence of HF. Femoral AT was the depot with the least macrophages infiltration and the largest adipocyte cell size and the only responsive to systemic and ex vivo proinflammatory stimulation (effect reversible by BNP). Low-grade inflammation reduced circulating adiponectin levels, while circulating BNP remained unchanged. CONCLUSIONS - This study demonstrates the regional variability in the responsiveness of human adipose tissue to systemic inflammation and suggests that BNP (not systemic inflammation) is the main driver of circulating adiponectin in patients with advanced atherosclerosis even in the absence of HF. Any interpretation of circulating adiponectin as a biomarker should take into account the underlying disease state, background inflammation, and BNP levels. © 2014 American Heart Association, Inc.
Authors & Co-Authors
Antonopoulos, Alexios S.
United Kingdom, Oxford
John Radcliffe Hospital
Psarros, Costas T.
Greece, Athens
School of Medicine
Ntusi, Ntobeko A.B.
United Kingdom, Oxford
John Radcliffe Hospital
Karamitsos, Theodoros D.
United Kingdom, Oxford
John Radcliffe Hospital
Sayeed, Rana A.
United Kingdom, Oxford
John Radcliffe Hospital
Wordsworth, Paul B.
United Kingdom, Oxford
University of Oxford
Tousoulis, Dimitrios M.
Greece, Athens
School of Medicine
Neubauer, Stefan
United Kingdom, Oxford
John Radcliffe Hospital
Channon, Keith Michael
United Kingdom, Oxford
John Radcliffe Hospital
Antoniades, Charalambos A.
United Kingdom, Oxford
John Radcliffe Hospital
Statistics
Citations: 93
Authors: 10
Affiliations: 3
Identifiers
Doi:
10.1161/ATVBAHA.114.303828
ISSN:
10795642
Research Areas
Cancer
Infectious Diseases
Noncommunicable Diseases
Study Design
Cross Sectional Study
Study Approach
Quantitative