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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma
Nature Genetics, Volume 44, No. 10, Year 2012
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Description
Primary angle closure glaucoma (PACG) is a major cause of blindness worldwide. We conducted a genome-wide association study including 1,854 PACG cases and 9,608 controls across 5 sample collections in Asia. Replication experiments were conducted in 1,917 PACG cases and 8,943 controls collected from a further 6 sample collections. We report significant associations at three new loci: rs11024102 in PLEKHA7 (per-allele odds ratio (OR) = 1.22; P = 5.33 × 10-12), rs3753841 in COL11A1 (per-allele OR = 1.20; P = 9.22 × 10-10) and rs1015213 located between PCMTD1 and ST18 on chromosome 8q (per-allele OR = 1.50; P = 3.29 × 10-9). Our findings, accumulated across these independent worldwide collections, suggest possible mechanisms explaining the pathogenesis of PACG. © 2012 Nature America, Inc. All rights reserved.
Authors & Co-Authors
Vithana, Eranga N.
Unknown Affiliation
Khor, Chiea Chuen
Unknown Affiliation
Qiao, Chunyan
Unknown Affiliation
Nongpiur, Monisha Esther
Unknown Affiliation
George, Ronnie Jacob
Unknown Affiliation
Chen, Lijia
Unknown Affiliation
Do, Tan
Unknown Affiliation
Abu-Amero, Khaled Khader
Unknown Affiliation
Huang, Chor Kai
Unknown Affiliation
Low, Sancy
Unknown Affiliation
Tajudin, Liza Sharmini A.
Unknown Affiliation
Perera, Shamira A.
Unknown Affiliation
Cheng, Ching Yu
Unknown Affiliation
Xu, Liang
Unknown Affiliation
Jia, Hongyan
Unknown Affiliation
Ho, Ching Lin
Unknown Affiliation
Sim, Kar Seng
Unknown Affiliation
Wu, Renyi
Unknown Affiliation
Tham, Clement C.Y.
Unknown Affiliation
Chew, Paul Tec Kwan
Unknown Affiliation
Su, Daniel H.
Unknown Affiliation
Oen, Francis T.
Unknown Affiliation
Sripriya, Sarangapani
Unknown Affiliation
Soumittra, Nagaswamy
Unknown Affiliation
Osman, Essam A.
Unknown Affiliation
Wong, Hong Tym
Unknown Affiliation
Tang, Guangxian
Unknown Affiliation
Fan, Sujie
Unknown Affiliation
Meng, Hailin
Unknown Affiliation
Huong, Dao T.L.
Unknown Affiliation
Wang, Hua
Unknown Affiliation
Feng, Bo
Unknown Affiliation
Baskaran, Mani
Unknown Affiliation
Shantha, Balekudaru
Unknown Affiliation
Ramprasad, Vedam L.
Unknown Affiliation
Kumaramanickavel, Govindasamy
Unknown Affiliation
Iyengar, Sudha K.
Unknown Affiliation
How, Alicia C.
Unknown Affiliation
Lee, Kelvin Y.
Unknown Affiliation
Sivakumaran, Theru A.
Unknown Affiliation
Yong, Victor H.K.
Unknown Affiliation
Ting, Serena M.L.
Unknown Affiliation
Li, Yang
Unknown Affiliation
Wang, Yaxing
Unknown Affiliation
Tay, Wan Ting
Unknown Affiliation
Sim, Xueling
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Lavanya, Raghavan
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Cornes, Belinda K.
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Zheng, Yingfeng
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Wong, Tina T.
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Loon, Seng Chee
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Yong, Vernon K.
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Waseem, Naushin
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Azhany, Yaakub
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Chia, Kee Seng
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Allingham, Robert Rand
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Hauser, Michael Arthur
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Lam, Dennis S.C.
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Hibberd, Martin Lloyd
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Bhattacharya, Shomi Shanker
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Zhang, Mingzhi
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Teo, Yik Ying
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Tan, Donald T.H.
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Jonas, Jost Bruno
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Tai, E. Shyong
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Saw, Seang Mei
Unknown Affiliation
Hon, Do Nhu
Unknown Affiliation
Al-Obeidan, Saleh Ali
Unknown Affiliation
Liu, Jianjun
Unknown Affiliation
Chau, Tran Nguyen Bich
Unknown Affiliation
Simmons, Cameron Paul
Unknown Affiliation
Bei, Jin Xin
Unknown Affiliation
Zeng, Yixin
Unknown Affiliation
Foster, Paul J.
Unknown Affiliation
Vijaya, Lingam
Unknown Affiliation
Wong, Tienyin
Unknown Affiliation
Pang, Chi Pui
Unknown Affiliation
Wang, Ningli
Unknown Affiliation
Aung, Tin
Unknown Affiliation
Statistics
Citations: 206
Authors: 79
Affiliations: 27
Identifiers
Doi:
10.1038/ng.2390
ISSN:
10614036
e-ISSN:
15461718
Research Areas
Genetics And Genomics
Health System And Policy
Study Design
Case-Control Study