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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21
Nature Genetics, Volume 43, No. 6, Year 2011
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Description
In search of common risk alleles for prostate cancer that could contribute to high rates of the disease in men of African ancestry, we conducted a genome-wide association study, with 1,047,986 SNP markers examined in 3,425 African-Americans with prostate cancer (cases) and 3,290 African-American male controls. We followed up the most significant 17 new associations from stage 1 in 1,844 cases and 3,269 controls of African ancestry. We identified a new risk variant on chromosome 17q21 (rs7210100, odds ratio per allele = 1.51, P = 3.4 × 10-13). The frequency of the risk allele is ̃5% in men of African descent, whereas it is rare in other populations (<1%). Further studies are needed to investigate the biological contribution of this allele to prostate cancer risk. These findings emphasize the importance of conducting genome-wide association studies in diverse populations. © 2011 Nature America, Inc. All rights reserved.
Authors & Co-Authors
Haiman, Christopher A.
United States, Los Angeles
Keck School of Medicine of Usc
Chen, Gary K.
United States, Los Angeles
Keck School of Medicine of Usc
Blot, William James
United States, Rockville
International Epidemiology Institute
United States, Nashville
Vanderbilt University Medical Center
Strom, Sara S.
United States, Houston
The University of Texas Md Anderson Cancer Center
Berndt, Sonja I.
United States, Rockville
National Cancer Institute Nci
Kittles, Rick A.
United States, Chicago
University of Illinois at Chicago
Rybicki, Benjamin A.
United States, Detroit
Henry Ford Hospital
Isaacs, William B.
United States, Baltimore
The Johns Hopkins Hospital
Ingles, Sue Ann
United States, Los Angeles
Keck School of Medicine of Usc
Stanford, Janet L.
United States, Seattle
Fred Hutchinson Cancer Research Center
Diver, William Ryan
United States, Kennesaw
American Cancer Society
Witte, John S.
United States, San Francisco
University of California, San Francisco
Hsing, Ann Wu
United States, Rockville
National Cancer Institute Nci
Nemesure, Barbara Berger
United States, Stony Brook
Renaissance School of Medicine at Stony Brook University
Rebbeck, Timothy R.
United States, Philadelphia
University of Pennsylvania Perelman School of Medicine
Cooney, Kathleen A.
United States, Ann Arbor
University of Michigan Medical School
Xu, Jienfiang Feng
United States, Winston Salem
Wake Forest University School of Medicine
Kibel, Adam S.
United States, St. Louis
Washington University in St. Louis
Hu, Jennifer J.
United States, Miami
Sylvester Comprehensive Cancer Center
John, Esther M.
United States, Fremont
Cancer Prevention Institute of California
Guèye, Sérigne Maguèye
Senegal, Dakar
Hopital Général de Grand Yoff
Watya, Stephen
Uganda, Kampala
Makerere University
Signorello, Lisa Beth
United States, Rockville
International Epidemiology Institute
United States, Nashville
Vanderbilt University Medical Center
Hayes, Richard B.
United States, New York
Nyu Langone Health
Wang, Zhaoming
United States, Rockville
National Cancer Institute Nci
Yeboah, Edward D.
Ghana, Accra
University of Ghana
Tettey, Yao
Ghana, Accra
University of Ghana
Cai, Qiuyin
United States, Nashville
Vanderbilt University Medical Center
Kolb, Suzanne
United States, Seattle
Fred Hutchinson Cancer Research Center
Ostrander, Elaine A.
United States, Bethesda
National Human Genome Research Institute Nhgri
Zeigler-Johnson, Charnita M.
United States, Philadelphia
University of Pennsylvania Perelman School of Medicine
Yamamura, Yuko
United States, Houston
The University of Texas Md Anderson Cancer Center
Neslund-Dudas, Christine M.
United States, Detroit
Henry Ford Hospital
Haslag-Minoff, Jennifer
United States, St. Louis
Washington University in St. Louis
Wu, William S.
United States, St. Louis
Washington University in St. Louis
Thomas, Venetta
United States, Miami
Sylvester Comprehensive Cancer Center
Allen, Glenn O.
United States, Miami
Sylvester Comprehensive Cancer Center
Murphy, Adam Bryant
United States, Evanston
Northwestern University
Chang, Baoli
United States, Philadelphia
University of Pennsylvania Perelman School of Medicine
Zheng, Siquan Lilly
United States, Winston Salem
Wake Forest University School of Medicine
Leske, Maria Cristina
United States, Stony Brook
Renaissance School of Medicine at Stony Brook University
Wu, Suhyuh
United States, Stony Brook
Renaissance School of Medicine at Stony Brook University
Ray, Anna M.
United States, Ann Arbor
University of Michigan Medical School
Hennis, Anselm J.M.
United States, Stony Brook
Renaissance School of Medicine at Stony Brook University
Jamaica, Kingston
The University of the West Indies
Barbados, Bridgetown
Ministry of Health Barbados
Thun, Michael J.
United States, Kennesaw
American Cancer Society
Carpten, John David
United States, Phoenix
Translational Genomics Research Institute
Casey, Graham R.
United States, Los Angeles
Keck School of Medicine of Usc
Carter, Erin N.
United States, Los Angeles
Keck School of Medicine of Usc
Duarte, Edder R.
United States, Los Angeles
Keck School of Medicine of Usc
Xia, Lucy Y.
United States, Los Angeles
Keck School of Medicine of Usc
Sheng, Xin
United States, Los Angeles
Keck School of Medicine of Usc
Wan, Peggy C.
United States, Los Angeles
Keck School of Medicine of Usc
Pooler, Loreall C.
United States, Los Angeles
Keck School of Medicine of Usc
Cheng, Iona Chi
United States, Honolulu
University of Hawaiʻi Cancer Center
Monroe, Kristine R.
United States, Los Angeles
Keck School of Medicine of Usc
Schumacher, Fredrick R.
United States, Los Angeles
Keck School of Medicine of Usc
Le Marchand, Loic̈
United States, Honolulu
University of Hawaiʻi Cancer Center
Kolonel, Laurence N.
United States, Honolulu
University of Hawaiʻi Cancer Center
Chanock, Stephen J.
United States, Rockville
National Cancer Institute Nci
Berg, David Van Den
United States, Los Angeles
Keck School of Medicine of Usc
Stram, Daniel O.
United States, Los Angeles
Keck School of Medicine of Usc
Henderson, Brian E.
United States, Los Angeles
Keck School of Medicine of Usc
Statistics
Citations: 210
Authors: 62
Affiliations: 28
Identifiers
Doi:
10.1038/ng.839
ISSN:
10614036
e-ISSN:
15461718
Research Areas
Cancer
Genetics And Genomics
Study Design
Case-Control Study
Participants Gender
Male