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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Multicenter validation of spin-density projection-assisted R2-MRI for the noninvasive measurement of liver iron concentration
Magnetic Resonance in Medicine, Volume 71, No. 6, Year 2014
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Description
Purpose: Magnetic resonance imaging (MRI)-based techniques for assessing liver iron concentration (LIC) have been limited by single scanner calibration against biopsy. Here, the calibration of spin-density projection-assisted (SDPA) R2-MRI (FerriScan®) in iron-overloaded β-thalassemia patients treated with the iron chelator, deferasirox, for 12 months is validated. Methods: SDPA R2-MRI measurements and percutaneous needle liver biopsy samples were obtained from a subgroup of patients (n=233) from the ESCALATOR trial. Five different makes and models of scanner were used in the study. Results LIC, derived from mean of MRI- and biopsy-derived values, ranged from 0.7 to 50.1 mg Fe/g dry weight. Mean fractional differences between SDPA R2-MRI- and biopsy-measured LIC were not significantly different from zero. They were also not significantly different from zero when categorized for each of the Ishak stages of fibrosis and grades of necroinflammation, for subjects aged 3 to <8 versus ≥8 years, or for each scanner model. Upper and lower 95% limits of agreement between SDPA R2-MRI and biopsy LIC measurements were 74 and -71%. Conclusion: The calibration curve appears independent of scanner type, patient age, stage of liver fibrosis, grade of necroinflammation, and use of deferasirox chelation therapy, confirming the clinical usefulness of SDPA R2-MRI for monitoring iron overload. © 2013 Wiley Periodicals, Inc.
Authors & Co-Authors
St. Pierre, Timothy G.
Australia, Perth
The University of Western Australia
El-Beshlawy, Amal M.
Egypt, Cairo
Faculty of Medicine
ElAlfy, Mohsen Saleh
Egypt, Cairo
Ain Shams University
Al-Jefri, Abdullah Hussain
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Al-Zir, Kusai Nasser
Syrian Arab Republic, Damascus
National Thalassemia Center
Daar, Shahina F.
Oman, Muscat
Sultan Qaboos University
Habr, Dany
Switzerland, Basel
Novartis International ag
Kriemler-Krahn, Ulrike
Switzerland, Basel
Novartis International ag
Taher, Ali T.
Lebanon, Beirut
American University of Beirut
Statistics
Citations: 109
Authors: 9
Affiliations: 8
Identifiers
Doi:
10.1002/mrm.24854
ISSN:
07403194
e-ISSN:
15222594
Research Areas
Health System And Policy