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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Genome-Wide linkage scan for primary open angle glaucoma: Influences of ancestry and age at diagnosis
PLoS ONE, Volume 6, No. 7, Article e21967, Year 2011
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Description
Primary open-angle glaucoma (POAG) is the most common form of glaucoma and one of the leading causes of vision loss worldwide. The genetic etiology of POAG is complex and poorly understood. The purpose of this work is to identify genomic regions of interest linked to POAG. This study is the largest genetic linkage study of POAG performed to date: genomic DNA samples from 786 subjects (538 Caucasian ancestry, 248 African ancestry) were genotyped using either the Illumina GoldenGate Linkage 4 Panel or the Illumina Infinium Human Linkage-12 Panel. A total of 5233 SNPs was analyzed in 134 multiplex POAG families (89 Caucasian ancestry, 45 African ancestry). Parametric and non-parametric linkage analyses were performed on the overall dataset and within race-specific datasets (Caucasian ancestry and African ancestry). Ordered subset analysis was used to stratify the data on the basis of age of glaucoma diagnosis. Novel linkage regions were identified on chromosomes 1 and 20, and two previously described loci-GLC1D on chromosome 8 and GLC1I on chromosome 15-were replicated. These data will prove valuable in the context of interpreting results from genome-wide association studies for POAG. © 2011 Crooks et al.
Authors & Co-Authors
Crooks, Kristy R.C.
United States, Durham
Duke University Medical Center
Allingham, Robert Rand
United States, Durham
Duke University Medical Center
Qin, Xuejun
United States, Durham
Duke University Medical Center
Liu, Yutao
United States, Durham
Duke University Medical Center
Gibson, Jason R.
United States, Durham
Duke University Medical Center
Santiago-Turla, Cecilia
United States, Durham
Duke University Medical Center
Larocque-Abramson, Karen R.
United States, Durham
Duke University Medical Center
Del Bono, Elizabeth
United States, Boston
Massachusetts Eye and Ear
Challa, Pratap
United States, Durham
Duke University Medical Center
Herndon, Leon W.
United States, Durham
Duke University Medical Center
Akafo, Stephen K.
Ghana, Accra
University of Ghana
Wiggs, Janey L.
United States, Boston
Massachusetts Eye and Ear
Schmidt, Silke
United States, Durham
Duke University Medical Center
Hauser, Michael Arthur
United States, Durham
Duke University Medical Center
Statistics
Citations: 17
Authors: 14
Affiliations: 3
Identifiers
Doi:
10.1371/journal.pone.0021967
e-ISSN:
19326203
Research Areas
Genetics And Genomics
Health System And Policy