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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Cross-reactivity of glycan-reactive HIV-1 broadly neutralizing antibodies with parasite glycans
Cell Reports, Volume 38, No. 13, Article 110611, Year 2022
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Description
The HIV-1 Envelope glycoprotein (Env) is the sole target for broadly neutralizing antibodies (bnAbs). Env is heavily glycosylated with host-derived N-glycans, and many bnAbs bind to, or are dependent upon, Env glycans for neutralization. Although glycan-binding bnAbs are frequently detected in HIV-infected individuals, attempts to elicit them have been unsuccessful because of the poor immunogenicity of Env N-glycans. Here, we report cross-reactivity of glycan-binding bnAbs with self- and non-self N-glycans and glycoprotein antigens from different life-stages of Schistosoma mansoni. Using the IAVI Protocol C HIV infection cohort, we examine the relationship between S. mansoni seropositivity and development of bnAbs targeting glycan-dependent epitopes. We show that the unmutated common ancestor of the N332/V3-specific bnAb lineage PCDN76, isolated from an HIV-infected donor with S. mansoni seropositivity, binds to S. mansoni cercariae while lacking reactivity to gp120. Overall, these results present a strategy for elicitation of glycan-reactive bnAbs which could be exploited in HIV-1 vaccine development. © 2022 The Author(s)
Authors & Co-Authors
Huettner, Isabella
United Kingdom, London
King's College London
Krumm, Stefanie A.
United Kingdom, London
King's College London
Serna, Sonia
Spain, Mendaro
Basque Research and Technology Alliance Brta
Brzezicka, Katarzyna Alicja
Spain, Mendaro
Basque Research and Technology Alliance Brta
van Diepen, Angela
Netherlands, Leiden
Leids Universitair Medisch Centrum
Allan, Fiona E.
United Kingdom, London
The Natural History Museum, London
Kimuda, Simon G.
United Kingdom, London
King's College London
Emery, Aidan M.
United Kingdom, London
The Natural History Museum, London
Allen, Susan A.
Unknown Affiliation
Kilembe, William
Unknown Affiliation
Lakhi, Shabir
Unknown Affiliation
Inambao, Mubiana
Unknown Affiliation
Karita, Etienne
Unknown Affiliation
Kamali, Anatoli
Unknown Affiliation
Sanders, Eduard Joachim
Unknown Affiliation
Anzala, Aggrey Omu
Unknown Affiliation
Edward, Vinodh Aroon
Unknown Affiliation
Bekker, Linda-Gail Gail
Unknown Affiliation
Tang, Jianming
Unknown Affiliation
Gilmour, Jill
Unknown Affiliation
Hunter, Eric
Unknown Affiliation
Price, Matt A.
Unknown Affiliation
Landais, Elise A.
United States, San Diego
International Aids Vaccine Initiative Neutralizing Antibody Center
United States, New York
International Aids Vaccine Initiative
Hokke, Cornelis Hendrik
Netherlands, Leiden
Leids Universitair Medisch Centrum
Reichardt, Niels Christian
Spain, Mendaro
Basque Research and Technology Alliance Brta
Spain, Madrid
Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina
Doores, Katie J.
United Kingdom, London
King's College London
Statistics
Citations: 3
Authors: 26
Affiliations: 9
Identifiers
Doi:
10.1016/j.celrep.2022.110611
ISSN:
22111247
Research Areas
Infectious Diseases
Study Design
Cohort Study