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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
A multinational study of neurological performance in antiretroviral therapy-naïve HIV-1-infected persons in diverse resource-constrained settings
Journal of NeuroVirology, Volume 17, No. 5, Year 2011
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Description
Little is known about how the prevalence and incidence of neurological disease in HIV-infected patients in resource-limited settings. We present an analysis of neurological and neurocognitive function in antiretroviral naïve individuals in multinational resource-limited settings. This prospective multinational cohort study, a substudy of a large international randomized antiretroviral treatment trial, was conducted in seven low-and middle-income countries in sub-Saharan Africa, South America, and Asia. Subjects were HIV-infected and met regional criteria to initiate antiretroviral therapy. Standardized neurological examination and a brief motor-based neuropsychological examination were administered. A total of 860 subjects were studied. Overall 249 (29%) had one or more abnormalities on neurological examinations, but there was a low prevalence of HIV-associated dementia (HAD) and minor neurocognitive disorder (MND). Twenty percent of subjects had evidence of peripheral neuropathy. There were significant differences across countries (p<0.001) in neuropsychological test performance. In this first multinational study of neurological function in antiretroviral naïve individuals in resource-limited settings, there was a substantial prevalence of peripheral neuropathy and low prevalence of dementia and other CNS diseases. There was significant variation in neurocognitive test performance and neurological examination findings across countries. These may reflect cultural differences, differences in HIV-related and unrelated diseases, and variations in test administration across sites. Longitudinal follow-up after antiretroviral treatment initiation may help to define more broadly the role of HIV in these differences as well as the impact of treatment on performance. © Journal of NeuroVirology, Inc. 2011.
Authors & Co-Authors
Robertson, Kevin R.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Kumwenda, Johnstone J.
Unknown Affiliation
Supparatpinyo, Khuanchai
Thailand, Chaing Mai
Chiang Mai University
Evans, Scott R.
United States, Cambridge
Harvard University
Campbell, Thomas B.
United States, Aurora
University of Colorado Anschutz Medical Campus
Price, Richard W.
United States, San Francisco
University of California, San Francisco
Murphy, Robert L.
United States, Evanston
Northwestern University
Hall, Colin D.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Marra, Christina M.
United States, Seattle
University of Washington
Marcus, Cheryl J.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Berzins, Baiba I.
United States, Evanston
Northwestern University
Masih, Reena
Unknown Affiliation
Santos, Breno Riegel
Unknown Affiliation
Silva, Marcus Tulius Teixeira Da
Brazil, Rio de Janeiro
Fundacao Oswaldo Cruz
Kumarasamy, Nagalingeswaran
Unknown Affiliation
Walawander, Ann L.
Unknown Affiliation
Nair, Apsara
Unknown Affiliation
Tripathy, Srikanth P.
Unknown Affiliation
Kanyama, Cecilia C.
Unknown Affiliation
Hosseinipour, Mina C.
Unknown Affiliation
Montano, Silvia
Unknown Affiliation
la Rosa, Alberto M.
Unknown Affiliation
Amod, Farida C.
Unknown Affiliation
Sanne, Ian
Unknown Affiliation
Firnhaber, Cynthia S.
Unknown Affiliation
Hakim, James Gita
Unknown Affiliation
Brouwers, Pim Y.
United States, Bethesda
Instituto Nacional de la Salud Mental
Statistics
Citations: 39
Authors: 27
Affiliations: 9
Identifiers
Doi:
10.1007/s13365-011-0044-3
ISSN:
15382443
Research Areas
Infectious Diseases
Mental Health
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative