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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Evaluation of the malaria rapid diagnostic test VIKIA malaria Ag Pf/Pan™ in endemic and non-endemic settings
Malaria Journal, Volume 12, No. 1, Article 188, Year 2013
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Description
Background: Malaria rapid diagnostic tests (RDTs) are a useful tool in endemic malaria countries, where light microscopy is not feasible. In non-endemic countries they can be used as complementary tests to provide timely results in case of microscopy inexperience. This study aims to compare the new VIKIA Malaria Ag Pf/Pan™ RDT with PCR-corrected microscopy results and the commonly used CareStart™ RDT to diagnose falciparum and non-falciparum malaria in the endemic setting of Bamako, Mali and the non-endemic setting of Lyon, France. Methods: Blood samples were collected during a 12-months and six-months period in 2011 from patients suspected to have malaria in Lyon and Bamako respectively. The samples were examined by light microscopy, the VIKIA Malaria Ag Pf/Pan™ test and in Bamako additionally with the CareStart™ RDT. Discordant results were corrected by real-time PCR. Sensitivity, specificity, positive predictive value and negative predictive value were used to evaluate test performance. Results: Samples of 877 patients from both sites were included. The VIKIA Malaria Ag Pf/Pan™ had a sensitivity of 98% and 96% for Plasmodium falciparum in Lyon and Bamako, respectively, performing similar to PCR-corrected microscopy. Conclusions: The VIKIA Malaria Ag Pf/Pan™ performs similar to PCR-corrected microscopy for the detection of P. falciparum, making it a valuable tool in malaria endemic and non-endemic regions. © 2013 Eibach et al.; licensee BioMed Central Ltd.
Authors & Co-Authors
Eibach, Daniel
France, Lyon
Chu de Lyon
Traoré, Boubacar M.
Mali, Bamako
Centre de Santé de Référence
Bouchrik, Mourad
Morocco, Agdal Rabat
Military Hospital Mohammed V
Coulibaly, Boubacar
Mali, Bamako
Centre de Santé de Référence
Coulibaly, Nianégué
Mali, Bamako
Centre de Santé de Référence
Siby, Fanta
Mali, Bamako
Ministry of Health
Bonnot, Guillaume
France, Villeurbanne
Université Claude Bernard Lyon 1
Bienvenu, Anne Lise
France, Lyon
Chu de Lyon
France, Villeurbanne
Université Claude Bernard Lyon 1
Picot, Stèphane
France, Lyon
Chu de Lyon
France, Villeurbanne
Université Claude Bernard Lyon 1
Statistics
Citations: 9
Authors: 9
Affiliations: 5
Identifiers
Doi:
10.1186/1475-2875-12-188
e-ISSN:
14752875
Research Areas
Infectious Diseases
Study Locations
Mali