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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Increasing incidence of malaria in children despite insecticide-treated bed nets and prompt anti-malarial therapy in Tororo, Uganda
Malaria Journal, Volume 11, Article 435, Year 2012
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Description
Background: The burden of malaria has decreased in parts of Africa following the scaling up of control interventions. However, similar data are limited from high transmission settings. Methods. A cohort of 100 children, aged six weeks to 10 months of age, were enrolled in an area of high malaria transmission intensity and followed through 48 months of age. Children were given a long-lasting insecticide-treated bed net (LLIN) at enrolment and received all care, including monthly blood smears and treatment with artemisinin-based combination therapy (ACT) for uncomplicated malaria, at a dedicated clinic. The incidence of malaria was estimated by passive surveillance and associations between malaria incidence and age, calendar time and season were measured using generalized estimating equations. Results: Reported compliance with LLINs was 98% based on monthly routine evaluations. A total of 1,633 episodes of malaria were observed, with a median incidence of 5.3 per person-year (PPY). There were only six cases of complicated malaria, all single convulsions. Malaria incidence peaked at 6.5 PPY at 23 months of age before declining to 3.5 PPY at 48 months. After adjusting for age and season, the risk of malaria increased by 52% from 2008 to 2011 (RR 1.52, 95% CI 1.10-2.09). Asymptomatic parasitaemia was uncommon (monthly prevalence <10%) and rarely observed prior to 24 months of age. Conclusions: In Tororo, despite provision of LLINs and prompt treatment with ACT, the incidence of malaria is very high and appears to be rising. Additional malaria control interventions in high transmission settings are likely needed. Trial registration. Current Controlled Trials Identifier NCT00527800. © 2012 Jagannathan et al.
Authors & Co-Authors
Jagannathan, P.
United States, San Francisco
Ucsf School of Medicine
Muhindo, Mary Kakuru
Uganda, Kampala
Infectious Diseases Research Collaboration
Kakuru, Abel
Uganda, Kampala
Infectious Diseases Research Collaboration
Arinaitwe, Emmanuel S.
Uganda, Kampala
Infectious Diseases Research Collaboration
Greenhouse, Bryan R.
United States, San Francisco
Ucsf School of Medicine
Tappero, Jordan W.
United States, Atlanta
Centers for Disease Control and Prevention
Rosenthal, Philip Jon
United States, San Francisco
Ucsf School of Medicine
Kaharuza, Frank M.
United States, Atlanta
Centers for Disease Control and Prevention
Kamya, Moses Robert K.
Uganda, Kampala
Makerere University
Dorsey, Grant M.
United States, San Francisco
Ucsf School of Medicine
Statistics
Citations: 91
Authors: 10
Affiliations: 4
Identifiers
Doi:
10.1186/1475-2875-11-435
e-ISSN:
14752875
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Cohort Study
Study Locations
Uganda