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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Endemic Lagos bat virus infection in Eidolon helvum
Epidemiology and Infection, Volume 140, No. 12, Year 2012
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Description
Phylogenetic analyses suggest lyssaviruses, including Rabies virus, originated from bats. However, the role of bats in the maintenance, transmission and evolution of lyssaviruses is poorly understood. A number of genetically diverse lyssaviruses are present in Africa, including Lagos bat virus (LBV). A high seroprevalence of antibodies against LBV was detected in Eidolon helvum bats. Longitudinal seroprevalence and age-specific seroprevalence data were analysed and capture-mark-recapture (CMR) analysis used to follow 98 bats over 18 months. These data demonstrate endemic infection, with evidence of horizontal transmission, and force of infection was estimated for differing age categories. The CMR analysis found survival probabilities of seronegative and seropositive bats were not significantly different. The lack of increased mortality in seropositive animals suggests infection is not causing disease after extended incubation. These key findings point towards acute transmission of bat lyssaviruses in adapted bat hosts that occurs at a far higher rate than the occurrence of disease. © Copyright Cambridge University Press 2012.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC9152339/bin/S0950268812000167sup001.doc
Authors & Co-Authors
Hayman, David T.S.
United Kingdom, Cambridge
University of Cambridge
United Kingdom, Addlestone
Animal and Plant Health Agency
United Kingdom, London
Zoological Society of London Institute of Zoology
United States, Fort Collins
Colorado State University
Fooks, Anthony Richard
United Kingdom, Addlestone
Animal and Plant Health Agency
United Kingdom, Liverpool
University of Liverpool
Rowcliffe, Justin Marcus
United Kingdom, London
Zoological Society of London Institute of Zoology
McCrea, Rachel
United Kingdom, Canterbury
University of Kent
Restif, Olivier
United Kingdom, Cambridge
University of Cambridge
Baker, Kate Susan
United Kingdom, Cambridge
University of Cambridge
United Kingdom, London
Zoological Society of London Institute of Zoology
Horton, Daniel L.
United Kingdom, Addlestone
Animal and Plant Health Agency
Suu-Ire, Richard Dery
Ghana, Accra
Wildlife Division of the Forestry Commission
Cunningham, Andrew Alexander
United Kingdom, London
Zoological Society of London Institute of Zoology
WOOD, JAMES L.N.
United Kingdom, Cambridge
University of Cambridge
Statistics
Citations: 45
Authors: 10
Affiliations: 7
Identifiers
Doi:
10.1017/S0950268812000167
ISSN:
09502688
e-ISSN:
14694409
Study Design
Cohort Study