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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Spirulina or dandelion-enriched diet of mothers alleviates lead-induced damages in brain and cerebellum of newborn rats
Food and Chemical Toxicology, Volume 50, No. 7, Year 2012
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Description
This study was aimed at evaluating the toxic effects of a prenatal exposure to lead acetate on brain tissues of newborn rats, and potent protective effects of spirulina (Arthropira platensis) or dandelion (Taraxacum officinalis) added to rat diet. Female rats were given a normal diet (control) or a diet enriched with spirulina or dandelion. Additionally, lead acetate was administered to one half of these rats through drinking water from the 5th day of gestation, to day 14 postpartum. Lead toxicity was assessed by measuring blood lead levels, brain weight, tissue damage, as well as protein content, lipid peroxidation and activities of antioxidant enzymes in brain tissues of neonates. Lead poisoning of mothers caused lead deposition in the brain and cerebellum of newborns and cerebellum tissue damages. Moreover, a significant decrease in weight and protein content of these tissues was found. Oxidative stress and changes in antioxidant enzyme activities in brain tissues were also recorded. Conversely, no such damages or biochemical changes were found in neonates from plant fed lead-poisoned mothers. These results strongly suggest that beneficial effects of spirulina- or dandelion-added diet on lead-intoxicated rats proceeded through the reduction of the lead-induced oxidative stress and related damages. © 2012 Elsevier Ltd.
Authors & Co-Authors
Gargouri, Mohamed
Tunisia, Sfax
Faculté Des Sciences de Sfax
France, Brest
Faculté Des Sciences et Techniques - Université de Brest Ubo
Tunisia, Hamam Lif
Centre de Biotechnologie de Borj Cédria
Ghorbel-Koubaa, Fatma
Tunisia, Sfax
Faculté Des Sciences de Sfax
Bonenfant-Magné, Michèle
France, Brest
Faculté Des Sciences et Techniques - Université de Brest Ubo
Magne, C.
France, Brest
Faculté Des Sciences et Techniques - Université de Brest Ubo
Dauvergne, Xavier
France, Brest
Faculté Des Sciences et Techniques - Université de Brest Ubo
Ksouri, Riadh
Tunisia, Hamam Lif
Centre de Biotechnologie de Borj Cédria
Krichen, Yousef
Tunisia, Ksour Essef
Ferme Marine Bio Algues Tunisie
Abdelly, Chédly
Tunisia, Hamam Lif
Centre de Biotechnologie de Borj Cédria
Feki, Abdelfattah El
Tunisia, Sfax
Faculté Des Sciences de Sfax
Statistics
Citations: 45
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.1016/j.fct.2012.04.003
ISSN:
02786915
e-ISSN:
18736351
Research Areas
Environmental
Maternal And Child Health
Participants Gender
Female