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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
B cell receptor repertoire kinetics after SARS-CoV-2 infection and vaccination
Cell Reports, Volume 38, No. 7, Article 110393, Year 2022
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Description
B cells are important in immunity to both severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection and vaccination, but B cell receptor (BCR) repertoire development in these contexts has not been compared. We analyze serial samples from 171 SARS-CoV-2-infected individuals and 63 vaccine recipients and find the global BCR repertoire differs between them. Following infection, immunoglobulin (Ig)G1/3 and IgA1 BCRs increase, somatic hypermutation (SHM) decreases, and, in severe disease, IgM and IgA clones are expanded. In contrast, after vaccination, the proportion of IgD/M BCRs increase, SHM is unchanged, and expansion of IgG clones is prominent. VH1-24, which targets the N-terminal domain (NTD) and contributes to neutralization, is expanded post infection except in the most severe disease. Infection generates a broad distribution of SARS-CoV-2-specific clones predicted to target the spike protein, while a more focused response after vaccination mainly targets the spike's receptor-binding domain. Thus, the nature of SARS-CoV-2 exposure differentially affects BCR repertoire development, potentially informing vaccine strategies. © 2022
Authors & Co-Authors
Mescia, Federica
United Kingdom, Cambridge
University of Cambridge
United Kingdom, Cambridge
School of Clinical Medicine
Bergamaschi, Laura
United Kingdom, Cambridge
University of Cambridge
United Kingdom, Cambridge
School of Clinical Medicine
Hosmillo, Myra D.T.
United Kingdom, Cambridge
Addenbrooke's Hospital
Hess, Christoph
United Kingdom, Cambridge
University of Cambridge
United Kingdom, Cambridge
School of Clinical Medicine
Switzerland, Basel
Universitätsspital Basel
Switzerland, Basel
Universitat Basel
Clatworthy, Menna Ruth
United Kingdom, Cambridge
University of Cambridge
United Kingdom, Cambridge
School of Clinical Medicine
United Kingdom, Hinxton
Wellcome Sanger Institute
Goodfellow, Ian Gordon
United Kingdom, Cambridge
Addenbrooke's Hospital
Matheson, Nicholas J.
United Kingdom, Cambridge
University of Cambridge
United Kingdom, Cambridge
School of Clinical Medicine
United Kingdom, Bristol
Nhs Blood and Transplant
Wills, Mark R.
United Kingdom, Cambridge
University of Cambridge
United Kingdom, Cambridge
School of Clinical Medicine
Gupta, Ravindra K.
United Kingdom, Cambridge
University of Cambridge
United Kingdom, Cambridge
School of Clinical Medicine
Bradley, John Richard
United Kingdom, Cambridge
School of Clinical Medicine
United Kingdom, Cambridge
Cambridge University Hospitals Nhs Foundation Trust
Bashford-Rogers, Rachael J.M.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Lyons, Paul A.
United Kingdom, Cambridge
University of Cambridge
United Kingdom, Cambridge
School of Clinical Medicine
Smith, Kenneth G.C.
United Kingdom, Cambridge
University of Cambridge
United Kingdom, Cambridge
School of Clinical Medicine
Statistics
Citations: 18
Authors: 13
Affiliations: 9
Identifiers
Doi:
10.1016/j.celrep.2022.110393
ISSN:
22111247
Research Areas
Covid