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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Alternative activation is an innate response to injury that requires CD4
+
T cells to be sustained during chronic infection
Journal of Immunology, Volume 179, No. 6, Year 2007
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Description
Alternatively activated macrophages (AAMΦ) are found in abundance during chronic Th2 inflammatory responses to metazoan parasites. Important roles for these macrophages are being defined, particularly in the context of Th2-mediated pathology and fibrosis. However, a full understanding of the requirements for alternative activation, particularly at the innate level, is lacking. We present evidence that alternative activation by the Th2 cytokines IL-4 and IL-13 is an innate and rapid response to tissue injury that takes place even in the absence of an infectious agent. This early response does not require CD4+ Th2 cells because it occurred in RAG-deficient mice. However, class II-restricted CD4+ T cell help is essential to maintain AAMΦ in response to infection, because AAMΦ were absent in RAG-deficient and MHC class II-deficient, but not B cell-deficient mice after chronic exposure to the nematode parasite, Brugia malayi. The absence of AAMΦ was associated with increased neutrophilia and reduced eosinophilia, suggesting that AAMΦ are involved in the clearance of neutrophils as well as the recruitment of eosinophils. Consistent with this hypothesis, AAMΦ show enhanced phagocytosis of apoptotic neutrophils, but not latex beads. Our data demonstrate that alternative activation by type 2 cytokines is an innate response to injury that can occur in the absence of an adaptive response. However, analogous to classical activation by microbial pathogens, Th2 cells are required for maintenance and full activation during the ongoing response to metazoan parasites. Copyright © 2007 by The American Association of Immunologists, Inc.
Authors & Co-Authors
Loke, P'Ng
United States, San Francisco
University of California, San Francisco
Gallagher, Iain J.
United Kingdom, Edinburgh
The University of Edinburgh
Nair, Meera G.
United Kingdom, Edinburgh
The University of Edinburgh
United States, Philadelphia
University of Pennsylvania School of Veterinary Medicine
Zang, Xingxing
United States, New York
Memorial Sloan-kettering Cancer Center
Brombacher, Frank
South Africa, Cape Town
University of Cape Town
Mohrs, Markus
United States, Saranac Lake
Trudeau Institute
Allison, James P.
United States, New York
Memorial Sloan-kettering Cancer Center
Allen, Judith E.
United Kingdom, Edinburgh
The University of Edinburgh
Statistics
Citations: 288
Authors: 8
Affiliations: 6
Identifiers
Doi:
10.4049/jimmunol.179.6.3926
ISSN:
00221767
e-ISSN:
15506606
Research Areas
Violence And Injury