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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Safety and efficacy of Zingiber officinale roots on fertility of male diabetic rats
Food and Chemical Toxicology, Volume 48, No. 10, Year 2010
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Description
The acute toxicity of methanolic and watery extracts of Zingiber officinale (ZO) roots in mice and their effects on fertility of male diabetic rats were carried out. The fertility experiment was done on six groups of male rats one of them was kept as normal control, while the others were rendered diabetic by subcutaneous injection of alloxan (120mgkg-1). One group was left as diabetic control, while the others were given orally either methanolic (100 and 200mgkg-1) or watery extract (150 and 300mgkg-1) for 65 consecutive days. The results showed that no mortalities occur when both extracts were given orally to mice in doses up to 5gkg-1 b.wt. Both extracts increased fertility index, sexual organs weight, serum testosterone level and sperm motility and count. Histopathological examination of the testes of diabetic rats showed mild to moderate degenerative changes of spermatogenic cells, diffuse edema and incomplete arrest of spermatogenesis. Treatment with ZO extracts caused alleviation of the testicular lesions that appeared in non-treated diabetic rats. Conclusively, extracts of ZO have high safety in mice and intake of ZO roots as a drink may be useful for diabetic patients who suffer from sexual impotency. © 2010 Elsevier Ltd.
Authors & Co-Authors
Shalaby, Mostafa Abbas
Egypt, Giza
Faculty of Veterinary Medicine
Hamowieh, A. R.
Syrian Arab Republic, Homs
Al-baath University
Statistics
Citations: 102
Authors: 2
Affiliations: 2
Identifiers
Doi:
10.1016/j.fct.2010.07.028
ISSN:
02786915
Research Areas
Sexual And Reproductive Health
Study Approach
Quantitative
Participants Gender
Male