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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Incidence of therapy-related acute leukaemia in mitoxantrone-treated multiple sclerosis patients in Germany
Therapeutic Advances in Neurological Disorders, Volume 5, No. 2, Year 2012
Notification
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Description
Background: The incidence of therapy-related acute leukaemia (TRAL) in mitoxantrone treatment in multiple sclerosis (MS) is controversially discussed. Methods and results: In a retrospective meta-analysis from six centres, we observed six cases of acute myeloid leukaemia (AML) (incidence 0.41% for patients with mean follow up after end of treatment of 3.6 years, n = 1.156; incidence 0.25% for all patients, n = 2.261). Potential influencing factors such as myelotoxic or glucocorticosteroid pretreatment/cotreatment were present in all but one case of TRAL. Between 1990 and 2010, 11 cases of TRAL were reported to the Drug Commission of the German Medical Association (estimated risk of 0.09-0.13%). Conclusions: Regional differences in reported TRAL incidence may point to confounding cofactors such as administration protocols and cotreatments. © 2012, SAGE Publications. All rights reserved.
Authors & Co-Authors
Zettl, Uwe Klaus
Germany, Bochum
Ruhr-universitat Bochum
Paul, Friedemann
Germany, Bochum
Ruhr-universitat Bochum
Flachenecker, Peter M.
Germany, Bochum
Ruhr-universitat Bochum
Zipp, Frauke
Germany, Bochum
Ruhr-universitat Bochum
Kieseier, Bernd C.S.
Germany, Bochum
Ruhr-universitat Bochum
Ziegler, Andreas E.
Germany, Bochum
Ruhr-universitat Bochum
Gold, Ralf
Germany, Bochum
Ruhr-universitat Bochum
Chan, Andrew K.P.
Germany, Bochum
Ruhr-universitat Bochum
Statistics
Citations: 35
Authors: 8
Affiliations: 1
Identifiers
Doi:
10.1177/1756285611433318
ISSN:
17562856
Study Design
Cohort Study
Study Approach
Systematic review