Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Defective pneumococcal-specific th1 responses in HIV-infected adults precedes a loss of control of pneumococcal colonization
Clinical Infectious Diseases, Volume 56, No. 2, Year 2013
Notification
URL copied to clipboard!
Description
Background. African adults infected with human immunodeficiency virus (HIV) have high rates of pneumococcal colonization and invasive disease. Here we have investigated the possibility that HIV disrupts the normal balance of pneumococcal-specific helper T cell (Th) 1/Th17 immunity to colonization, resulting in a more permissive nasopharyngeal niche.Methods. One hundred thirty-six HIV-infected and -uninfected Malawian adults were enrolled in the study. Changes in rates and composition of nasopharyngeal pneumococcal colonization were analyzed using microarray. The underlying pneumococcal- specific Th1/Th17 responses associated with altered pneumococcal colonization were investigated using flow cytometry.Results. We find that pneumococcal carriage is only modestly increased in asymptomatic HIV-infected Malawian adults but that colonization rates rise dramatically during symptomatic disease (HIVneg 13%, HIVasy 19%, and HIVsym 38%). These rates remain high in subjects established on antiretroviral therapy (ART): 33% (at 6-12 months) and 52% (at 18 months), with HIV-infected individuals carrying a broader range of invasive and noninvasive serotypes compared with HIV-negative controls. The frequency of multiple serotype carriage (>1 serotype HIV neg 26%, HIVasy 30%, HIVsym 31%, HIV ART 31%) is not affected. These changes in colonization are associated with generalized CD4 T-cell depletion, impaired antigen-specific proliferation, and a defect in pneumococcal-specific T-cell interferon-γ but not interleukin 17 production.Conclusions. These data reveal the persistently poor control of pneumococcal colonization in HIV-infected adults following immune ART-mediated reconstitution, highlighting a potential reservoir for person-to-person spread and vaccine escape. Novel approaches to control colonization either through vaccination or through improvements in the quality of immune reconstitution are required. © 2012 The Author. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Glennie, Sarah J.
Malawi, Zomba
University of Malawi
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Banda, Dominic H.
Malawi, Zomba
University of Malawi
Gould, Katherine A.
United Kingdom, London
St George’s, University of London
Hinds, Jason
United Kingdom, London
St George’s, University of London
Kamng'ona, Arox W.
Malawi, Zomba
University of Malawi
Everett, Dean B.
Malawi, Zomba
University of Malawi
Williams, Neil A.
United Kingdom, Bristol
University of Bristol
Heyderman, Robert Simon
Malawi, Zomba
University of Malawi
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Statistics
Citations: 44
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1093/cid/cis842
ISSN:
10584838
e-ISSN:
15376591
Research Areas
Infectious Diseases