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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Genome-wide sequencing data reveals virulence factors implicated in banana Xanthomonas wilt
FEMS Microbiology Letters, Volume 310, No. 2, Year 2010
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Description
Banana Xanthomonas wilt is a newly emerging disease that is currently threatening the livelihoods of millions of farmers in East Africa. The causative agent is Xanthomonas campestris pathovar musacearum (Xcm), but previous work suggests that this pathogen is much more closely related to species Xanthomonas vasicola than to X. campestris. We have generated draft genome sequences for a banana-pathogenic strain of Xcm isolated in Uganda and for a very closely related strain of X. vasicola pathovar vasculorum, originally isolated from sugarcane, that is nonpathogenic on banana. The draft sequences revealed overlapping but distinct repertoires of candidate virulence effectors in the two strains. Both strains encode homologues of the Pseudomonas syringae effectors HopW, HopAF1 and RipT from Ralstonia solanacearum. The banana-pathogenic and non-banana-pathogenic strains also differed with respect to lipopolysaccharide synthesis and type-IV pili, and in at least several thousand single-nucleotide polymorphisms in the core conserved genome. We found evidence of horizontal transfer between X. vasicola and very distantly related bacteria, including members of other divisions of the Proteobacteria. The availability of these draft genomes will be an invaluable tool for further studies aimed at understanding and combating this important disease. © 2010 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved.
Authors & Co-Authors
Studholme, David John
United Kingdom, Exeter
University of Exeter
United Kingdom, Norwich
The Sainsbury Laboratory
Kemen, Eric M.
United Kingdom, Norwich
The Sainsbury Laboratory
MacLean, Daniel
United Kingdom, Norwich
The Sainsbury Laboratory
Schornack, Sebastian
United Kingdom, Norwich
The Sainsbury Laboratory
Aritua, Valentine
Uganda, Kampala
Kawanda Agricultural Research Institute
Thwaites, Richard M.
United Kingdom, York
Fera Science Limited
Grant, Murray R.
United Kingdom, Exeter
University of Exeter
Smith, Julian J.
United Kingdom, York
Fera Science Limited
Jones, Jonathan D.G.
United Kingdom, Norwich
The Sainsbury Laboratory
Statistics
Citations: 70
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.1111/j.1574-6968.2010.02065.x
ISSN:
03781097
e-ISSN:
15746968
Study Locations
Multi-countries
Uganda