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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Paroxetine serum concentrations in depressed patients and response to treatment
Pharmacopsychiatry, Volume 38, No. 3, Year 2005
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Description
Introduction: There is no established relationship between the serum concentration of selective serotonin reuptake inhibitors (SSRIs) and clinical response in depressed patients. Methods: We analyzed paroxetine concentrations in serum of 46 depressed patients during treatment with a fixed dosage of 40 mg paroxetine. Results: After 5 weeks 29 patients responded to treatment, while 17 did not. Analysis of variance with repeated measures (ANOVA-rm) revealed a significant effect of "response" with responders having lower serum concentrations throughout the treatment period, when compared to non-responders. After 2, 3, and 4 weeks of treatment, we could define an upper threshold of paroxetine serum concentrations (week 1:22.7 ng/mL; week 2:43 ng/mL; week 3:53.4 ng/mL; week 4:39.1 ng/mL) above which response to treatment was unlikely. Conclusion: We conclude that - in contrast to other pharmacological approaches - high rather than low drug serum concentrations may be associated with non-response in paroxetine treatment of depressed patients. © Georg Thieme Verlag KG Stuttgart.
Authors & Co-Authors
Gilles, M.
Unknown Affiliation
Deuschle, Michael
Unknown Affiliation
Kellner, S.
Unknown Affiliation
Shams, Mohamed E.E.
Unknown Affiliation
Krumm, B.
Unknown Affiliation
Härtter, S.
Unknown Affiliation
Heuser, Isabella
Unknown Affiliation
Hiemke, Christoph
Unknown Affiliation
Statistics
Citations: 8
Authors: 8
Affiliations: 6
Identifiers
Doi:
10.1055/s-2005-864121
ISSN:
01763679