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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
HLA-E*0101 allele in homozygous state favors severe bacterial infections in sickle cell anemia
Human Immunology, Volume 68, No. 10, Year 2007
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Description
Severe bacterial infections are the major causes of morbidity and mortality in sickle cell anemia (SCA) but are poorly explained. The distribution of a bi-allelic polymorphism (Arg107Gly) of human leukocyte antigen-E (HLA-E) locus was investigated in 144 SCA patients, most of whom originated from from sub-Saharan Africa. Among them, 73 presented with at least one severe bacterial infection, whereas 71 did not. The HLA-E*0101/E*0101 genotype was more frequent among the group with infections than their counterparts (47% vs 21%; p corrected = 0.003). This genetic association is of relevance, given the emerging evidence for the involvement of HLA-E molecules in host response to pathogens. © 2007 American Society for Histocompatibility and Immunogenetics.
Authors & Co-Authors
Tamouza, Ryad
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Busson, Marc
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Fortier, Catherine
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Diagne, Ibrahima
Senegal, Dakar
Albert Royer Hospital
Diallo, Dapa Aly
Mali, Bamako
University of Bamako Faculty of Medicine, Pharmacy and Odonto-stomatology
Sloma, Ivan
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Contouris, Hector
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Krishnamoorthy, Rajagopal
France, Paris
Hôpital Robert-debré Ap-hp
Labié, Dominique
France, Paris
Institut Cochin
Girot, Robert
France, Paris
Hôpital Tenon
Charron, Dominique J.
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Statistics
Citations: 35
Authors: 11
Affiliations: 6
Identifiers
Doi:
10.1016/j.humimm.2007.08.260
ISSN:
01988859
Research Areas
Genetics And Genomics