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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Muscle oxygen supply impairment during maximal exercise in patients undergoing dialysis therapy
Respiratory Physiology and Neurobiology, Volume 319, Article 104169, Year 2024
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Description
This study aimed to investigate whether Chronic Kidney Disease (CKD) influences O2 supply including O2 delivery and release to the active muscles during maximal physical exercise. Twelve CKD patients undergoing dialysis therapy (HD group) and twelve healthy adults (CTR group) performed an incremental exercise test to determine maximal oxygen uptake (VO2peak). Throughout the exercise, near-infrared spectroscopy allowed the investigation of changes in oxyhemoglobin (∆O2Hb), deoxyhemoglobin (∆HHb), and total hemoglobin (∆THb) in the vastus lateralis muscle. VO2peak was significantly lower in HD group. In addition, HD patients had impaired changes in muscular oxygenation (∆HHb and ∆O2Hb) and blood volume (∆THb) during the exercise (p < 0.05). Moreover, a positive correlation was observed between VO2peak and muscle blood volume (∆THb) in both groups (p < 0.05). This study provides the first evidence that HD patients displayed lower VO2peak and blunted muscular deoxyhemoglobin increase during exercise. This result supports the hypothesis of an increase in oxygen affinity and/or mitochondrial dysfunction in this population. © 2023 Elsevier B.V.
Authors & Co-Authors
Machfer, Amal
Tunisia, Sfax
University of Sfax
Tagougui, Sémah
France, Dunkerque
Université du Littoral Côte D‘opale
Canada, Montreal
Institut de Recherches Cliniques de Montréal
Fekih, Nadia
Tunisia, Sfax
University of Sfax
Ibn Hadj Amor, Hassen
Tunisia, Mahdia
Hôpital Tahar Sfar
Bouzid, Mohamed Amine
Tunisia, Sfax
University of Sfax
Cthourou, Hamdi C.
Tunisia, Tunis
Sport et Santé
Statistics
Citations: 1
Authors: 6
Affiliations: 5
Identifiers
Doi:
10.1016/j.resp.2023.104169
ISSN:
15699048
Research Areas
Noncommunicable Diseases
Study Design
Cross Sectional Study