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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Effect of gestational age on levels of serum alkaline phosphatase isoenzymes in healthy pregnant women
International Journal of Gynecology and Obstetrics, Volume 48, No. 1, Year 1995
Notification
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Description
Objectives: To confirm that the bone isoenzyme of alkaline phosphatase (ALP) contributes significantly to the increased ALP in normal pregnancy, and to determine the gestational age at which the increase occurs. Methods: Cross-sectional determinations of serum total, bone and placental ALP were carried out in 67 normal pregnant women. The results were compared with those of 18 normal age-matched non-pregnant controls using Student's t-test. Results: At both 31-32 weeks and 38 weeks of gestation, serum activities of bone ALP were increased significantly (P < 0.05 and P < 0.001, respectively) when compared with controls. The percentage contribution of bone ALP to the total was higher at 31-32 weeks and lower at 38 weeks when compared with the contribution from placental ALP. Conclusion: Knowledge of time of elevation of serum bone ALP activity in normal pregnancy will be helpful in the interpretation of elevated serum total ALP activity during pregnancy. © 1995.
Authors & Co-Authors
Okesina, A. B.
Nigeria, Ilorin
University of Ilorin
Donaldson, D.
United Kingdom, Redhill
East Surrey Hospital
Lascelles, P. T.
United Kingdom, London
National Hospital for Neurology and Neurosurgery
Morris, P.
United Kingdom, London
National Hospital for Neurology and Neurosurgery
Statistics
Citations: 36
Authors: 4
Affiliations: 3
Identifiers
Doi:
10.1016/0020-7292(94)02248-8
ISSN:
00207292
Research Areas
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Cross Sectional Study
Participants Gender
Female