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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Maternal human immunodeficiency virus 1 infection and intrauterine growth: A prospective cohort study in butare, Rwanda
Pediatric Infectious Disease Journal, Volume 13, No. 2, Year 1994
Notification
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Description
A prospective cohort study of 318 human immunodeficiency virus 1 (HlV-l)-infected and 309 seronegative pregnant women was carried out in Butare, Rwanda. Birth weight was significantly lower among singleton infants born alive to HIV-l-infected mothers compared with those born alive to seronegative mothers (2706 g vs. 2825 g; P = 0.002). Crown-to-heel length, head circumference, chest circumference and placental weight were also reduced. Maternal HIV-1 infection was significantly associated with intrauterine growth retardation but not with preterm birth. Differences in the body mass index and weight/head ratio suggest that the adverse impact on live born infants may have been most severe towards the end of pregnancy, resulting in a lean infant with a relatively large head. The higher frequency of intrauterine growth retardation could not be explained by potential confounding factors such as maternal cigarette smoking, history of sexually transmitted diseases or sociodemographic characteristics. The neonatal physical examination did not reveal any differences in clinical signs or symptoms within 48 hours of birth except for the presence of conjunctivitis which was more common among infants of HIV-l-infected mothers. The perinatal and neonatal mortality rates were not significantly affected by maternal HIV-1 status. © 1994 by Williams & Wilkins.
Authors & Co-Authors
Bulterys, Marc G.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Rwanda, Butare
University of Rwanda
Chao, Ann
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Rwanda, Butare
University of Rwanda
Munyemana, Sosthène
Rwanda, Kigali
University Hospital
Kurawige, Jean Baptiste
Rwanda, Butare
University of Rwanda
Nawrocki, Paula
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Rwanda, Butare
University of Rwanda
Habimana, Phocas
Rwanda, Butare
University of Rwanda
Kageruka, Martin
Rwanda, Kigali
University Hospital
Mukantabana, Spéciose
Rwanda, Kigali
University Hospital
Mbarutso, Etienne
Rwanda, Kigali
University Hospital
Dushimimana, Abel
Rwanda, Butare
University of Rwanda
Saah, Alfred J.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Statistics
Citations: 82
Authors: 11
Affiliations: 3
Identifiers
Doi:
10.1097/00006454-199402000-00003
ISSN:
08913668
e-ISSN:
15320987
Research Areas
Infectious Diseases
Maternal And Child Health
Sexual And Reproductive Health
Substance Abuse
Study Design
Cohort Study
Study Approach
Quantitative
Study Locations
Rwanda
Participants Gender
Female