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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Candidate genes linking maternal nutrient exposure to offspring health via DNA methylation: A review of existing evidence in humans with specific focus on one-carbon metabolism
International Journal of Epidemiology, Volume 47, No. 6, Year 2018
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Description
Background: Mounting evidence suggests that nutritional exposures during pregnancy influence the fetal epigenome, and that these epigenetic changes can persist postnatally, with implications for disease risk across the life course. Methods: We review human intergenerational studies using a three-part search strategy. Search 1 investigates associations between preconceptional or pregnancy nutritional exposures, focusing on one-carbon metabolism, and offspring DNA methylation. Search 2 considers associations between offspring DNA methylation at genes found in the first search and growth-related, cardiometabolic and cognitive outcomes. Search 3 isolates those studies explicitly linking maternal nutritional exposure to offspring phenotype via DNA methylation. Finally, we compile all candidate genes and regions of interest identified in the searches and describe their genomic locations, annotations and coverage on the Illumina Infinium Methylation beadchip arrays. Results: We summarize findings from the 34 studies found in the first search, the 31 studies found in the second search and the eight studies found in the third search. We provide details of all regions of interest within 45 genes captured by this review. Conclusions: Many studies have investigated imprinted genes as priority loci, but with the adoption of microarray-based platforms other candidate genes and gene classes are now emerging. Despite a wealth of information, the current literature is characterized by heterogeneous exposures and outcomes, and mostly comprise observational associations that are frequently underpowered. The synthesis of current knowledge provided by this review identifies research needs on the pathway to developing possible early life interventions to optimize lifelong health. © The Author(s) 2018.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC6280938/bin/dyy153_supplementary_material_1.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC6280938/bin/dyy153_supplementary_material_2.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC6280938/bin/dyy153_supplementary_table_1.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC6280938/bin/dyy153_supplementary_table_2.pdf
Authors & Co-Authors
James, Philip T.
United Kingdom, London
Medical Research Council
Sajjadi, Sara
India, Hyderabad
Centre for Cellular and Molecular Biology India
Tomar, Ashutosh Singh
India, Hyderabad
Centre for Cellular and Molecular Biology India
Saffari, Ayden
United Kingdom, London
Medical Research Council
Fall, Caroline H.D.
United Kingdom, Southampton
Southampton General Hospital
Prentice, Andrew M.
United Kingdom, London
Medical Research Council
Shrestha, Smeeta
India, Hyderabad
Centre for Cellular and Molecular Biology India
India, Bengaluru
Dayananda Sagar University
Issarapu, Prachand
India, Hyderabad
Centre for Cellular and Molecular Biology India
Yadav, Dilip Kumar
India, Hyderabad
Centre for Cellular and Molecular Biology India
Kaur, Lovejeet
India, Hyderabad
Centre for Cellular and Molecular Biology India
Lillycrop, Karen A.
United Kingdom, Southampton
University of Southampton
Silver, Matt J.
United Kingdom, London
Medical Research Council
Ratan Chandak, Giriraj Ratan
India, Hyderabad
Centre for Cellular and Molecular Biology India
Statistics
Citations: 51
Authors: 13
Affiliations: 5
Identifiers
Doi:
10.1093/ije/dyy153
ISSN:
03005771
Research Areas
Environmental
Genetics And Genomics
Health System And Policy
Maternal And Child Health
Sexual And Reproductive Health