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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Association study of CARD8 (p.C10X) and NLRP3 (p.Q705K) variants with rheumatoid arthritis in French and Tunisian populations
International Journal of Immunogenetics, Volume 39, No. 2, Year 2012
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Description
The objective of the study was to investigate the association of caspase activating and recruitment domain 8 (CARD8) and nucleotide-binding oligomerization domain, leucine-rich repeat and pyrin domain containing 3 (NLRP3) polymorphisms with rheumatoid arthritis (RA) in Tunisian and French populations. CARD8 (c.30T>A, rs2043211) and NLRP3 (c.2113C>A, rs35829419) single nucleotide polymorphisms (SNPs) were genotyped in 100 French RA trio families and 141 Tunisian patients with RA and 191 unrelated healthy controls, using TaqMan® allelic discrimination assay. The genetic analyses for the association and linkage in French families were performed using the comparison of allelic frequencies (AFBAC), the genotype relative risk (GRR) and the transmission disequilibrium test (TDT). Data for case and control samples were analysed by chi-square-test, GRR and odds ratio (OR). No significant differences between alleles and genotypes frequencies were detected in French trio and Tunisian patients with RA and controls, either with CARD8 or with NLRP3 SNPs both in French and in Tunisian populations. Moreover, stratifying patients according to the presence of rheumatoid factor (RF), anti-cyclic peptides antibodies (ACPA), erosion, nodules, other autoimmune disease or HLA-DRB1*04-positive subgroups did not show any significant association with CARD8 or NLRP3 (P≥0.05). This study suggests that variations in the innate immunity genes CARD8 (p.C10X) and NLRP3 (p.Q705K) have no effect on RA susceptibility either in the Tunisian or in the French population. © 2011 Blackwell Publishing Ltd.
Authors & Co-Authors
Ben Hamad, Mariem
Tunisia, Sfax
Faculty of Medicine of Sfax
Cornélis, François B.
France, Evry
Genopole
Marzouk, Sameh
Tunisia, Sfax
Chu Hedi-chaker
Chabchoub, Ghazi
Tunisia, Sfax
Faculty of Medicine of Sfax
Bahloul, Zouhir
Tunisia, Sfax
Chu Hedi-chaker
REBAI, AHMED
Tunisia, Sfax
Centre de Biotechnologie de Sfax
Fakhfakh, Faiza
Tunisia, Sfax
Faculty of Medicine of Sfax
Ayadi, Hammadi
Tunisia, Sfax
Faculty of Medicine of Sfax
Petit-Teixeira, Élisabeth
France, Evry
Genopole
Maalej, Abdellatif
Tunisia, Sfax
Faculty of Medicine of Sfax
Statistics
Citations: 45
Authors: 10
Affiliations: 4
Identifiers
Doi:
10.1111/j.1744-313X.2011.01070.x
ISSN:
17443121
e-ISSN:
1744313X
Research Areas
Genetics And Genomics
Study Design
Cross Sectional Study
Case-Control Study