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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Initial HIV-1 antigen-specific CD8
+
T cells in acute HIV-1 infection inhibit transmitted/founder virus replication
Journal of Virology, Volume 86, No. 12, Year 2012
Notification
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Description
CD8-mediated virus inhibition can be detected in HIV-1-positive subjects who naturally control virus replication. Characterizing the inhibitory function of CD8+ T cells during acute HIV-1 infection (AHI) can elucidate the nature of the CD8+ responses that can be rapidly elicited and that contribute to virus control. We examined the timing and HIV-1 antigen specificity of antiviral CD8+ T cells during AHI. Autologous and heterologous CD8+ T cell antiviral functions were assessed longitudinally during AHI in five donors from the CHAVI 001 cohort using a CD8+ T cell-mediated virus inhibition assay (CD8 VIA) and transmitted/ founder (T/F) viruses. Potent CD89+ antiviral responses against heterologous T/F viruses appeared during AHI at the first time point sampled in each of the 5 donors (Fiebig stages 1/2 to 5). Inhibition of an autologous T/F virus was durable to 48 weeks; however, inhibition of heterologous responses declined concurrent with the resolution of viremia. HIV-1 viruses from 6 months postinfection were more resistant to CD8+-mediated virus inhibition than cognate T/F viruses, demonstrating that the virus escapes early from CD8+ T cell-mediated inhibition of virus replication. CD8+ T cell antigen-specific subsets mediated inhibition of T/F virus replication via soluble components, and these soluble responses were stimulated by peptide pools that include epitopes that were shown to drive HIV-1 escape during AHI. These data provide insights into the mechanisms of CD8-mediated virus inhibition and suggest that functional analyses will be important for determining whether similar antigen-specific virus inhibition can be induced by T cell-directed vaccine strategies. © 2012, American Society for Microbiology.
Authors & Co-Authors
Freel, Stephanie A.
United States, Durham
Duke University
Picking, Ralph A.
Unknown Affiliation
Ferrari, Guido
Unknown Affiliation
Ding, Haitao
United States, Birmingham
The University of Alabama at Birmingham
Ochsenbauer, Christina
United States, Birmingham
The University of Alabama at Birmingham
Kappes, John
United States, Birmingham
The University of Alabama at Birmingham
Kirchherr, Jennifer L.
United States, Durham
Duke University
Soderberg, Kelly A.
United States, Durham
Duke University
Weinhold, Kent J.
United States, Durham
Duke University
Cunningham, Coleen K.
Unknown Affiliation
Denny, Thomas N.
United States, Durham
Duke University
Crump, John A.
Tanzania, Moshi
Kilimanjaro Christian Medical Centre
Cohen, Myron S.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
McMichael, Andrew James
United Kingdom, Oxford
University of Oxford
Haynes, Barton F.
United States, Durham
Duke University
Tomaras, Georgia D.
United States, Durham
Duke University
Statistics
Citations: 65
Authors: 16
Affiliations: 5
Identifiers
Doi:
10.1128/JVI.00437-12
ISSN:
0022538X
e-ISSN:
10985514
Research Areas
Infectious Diseases
Study Design
Cohort Study