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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Mechanisms mediating the antiproliferative effects of nitric oxide in cultured human airway smooth muscle cells
FEBS Letters, Volume 506, No. 2, Year 2001
Notification
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Description
We have characterised the mechanisms involved in the antiproliferative effect of NO in human airway smooth muscle cells (HASMC). S-Nitroso-N-acetyl penicillamine, a nitric oxide donor, inhibited proliferation in both G1 and S phases of the cell cycle. Additionally, experiments with 8-bromo-cGMP, haemoglobin, a NO scavenger and zaprinast, a cGMP-specific phosphodiesterase inhibitor, showed that both effects were NO-mediated. The G1 phase inhibition was cGMP-dependent whereas the S phase inhibition was due to a cGMP-independent inhibition of ribonucleotide reductase. These results demonstrate that NO inhibits HASMC proliferation by cGMP-dependent and -independent mechanisms acting at distinct points in the cell cycle. © 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
Authors & Co-Authors
Hamad, Ahmed M.
Egypt, Mansoura
Faculty of Medicine
Knox, Alan J.
United Kingdom, Nottingham
Nottingham City Hospital
Statistics
Citations: 30
Authors: 2
Affiliations: 2
Identifiers
Doi:
10.1016/S0014-5793(01)02883-6
ISSN:
00145793