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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Prognostic value of proliferation markers: Immunohistochemical Ki-67 expression and cytometric S-phase fraction of women with breast cancer in Libya
Journal of Cancer, Volume 3, No. 1, Year 2012
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Description
Background: We evaluated the association of the immunohistochemical Ki-67 expression, and S-phase fraction with clinicopathological variables and patient outcome. Patients and methods: Histological samples from 100 primary Libyan breast carcinoma patients were retrospectively studied with monoclonal antibody to Ki-67. S-phase fraction was determined by DNA image cytometry. Results: The median Ki-67 percentage for all tumors was 27.5%, ranging from 1 to 80% and the median S-phase fraction (SPF) was 11%, ranging from 0 to 62 %. Tumors with high Ki-67 expression were found in 76% of patients and with high SPF values in 56%. Ki-67 expression was more frequent in tumors with high SPF than low SPF. High Ki-67 and high SPF were associated with advanced stages, poor differentiation of tumors, positive lymph nodes, and distant metastasis. The Ki-67 was associated with hormone receptor negative tumors. The SPF was higher in young patients (<50 years) than in older patients. In the overall population (median follow-up 49 months), patients with high Ki-67 and high SPF had shorter survival time and predicted recurrence than patients with low Ki-67 and low SPF. In a Cox multivariate analysis, high SPF (p= 0.007), hormonal status (p= 0.001) and clinical stage (p=0.005) were independent predictors of disease-specific survival. The Ki-67 (p=0.065) in borderline significance proved to be independent predictor of disease-free survival. The SPF showed more statistically significance with a high grade of malignancy and survival time than Ki-67. Conclusions: The SPF value is useful cell proliferation marker to assess tumor prognosis. These markers may reflect the aggressive behavior of Libyan breast cancer and predict of the recurrence. It is therefore important to take these markers into consideration to select a high risk subgroup of the patients for intensive treatment. © Ivyspring International Publisher.
Authors & Co-Authors
Ermiah, Eramah
Finland, Turku
Turun Yliopisto
Libya, Misurata
National Cancer Institute
Buhmeida, Abdelbaset
Saudi Arabia, Jeddah
King Abdulaziz University
Abdalla, Fathi B.Elmabrouk
Libyan Arab Jamahiriya
Misurata Cancer Institute
Khaled, Ben Romdhane
Tunisia, Tunis
Institut Salah Azaiez de Tunis
Salem, Nada
Saudi Arabia, Jeddah
King Abdulaziz University
Pyrhönen, Seppo Olavi
Finland, Turku
Turun Yliopisto
Collãn, Yrjöu Urho Ilmari
Finland, Turku
Turun Yliopisto
Statistics
Citations: 42
Authors: 7
Affiliations: 5
Identifiers
Doi:
10.7150/jca.4944
e-ISSN:
18379664
Research Areas
Cancer
Genetics And Genomics
Health System And Policy
Study Design
Cross Sectional Study
Cohort Study
Study Locations
Libya
Participants Gender
Female