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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Human leukocyte antigen class i and II alleles and overall survival in diffuse large B-cell lymphoma and follicular lymphoma
TheScientificWorldJournal, Volume 11, Year 2011
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Description
Genetic variation in the 6p21 chromosomal region, including human leukocyte antigen (HLA) genes and tumor necrosis factor (TNF), has been linked to both etiology and clinical outcomes of lymphomas. We estimated the effects of HLA class I (A, B, and C), class II DRB1 alleles, and the ancestral haplotype (AH) 8.1 (HLA A(*)01-B(*)08-DRB1(*)03-TNF-308A) on overall survival (OS) among patients with diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL) in a population-based study of non-Hodgkin lymphoma. During a median followup of 89 months, 31 (52 of 166) DLBCL and 28 (46 of 165) FL patients died. Using multivariate Cox regression models, we observed statistically significant associations between genetic variants and survival: HLA-Cw(*)07:01 was associated with poorer OS among DLBCL patients (Hazard ratio [HR]=1.76, 95 confidence interval [CI]=1.01-3.05); HLA-A(*)01:01 was associated with poorer OS (HR=2.23, 95 CI=1.24-4.01), and HLA-DRB1(*)13 (HR=0.12, 95 CI=0.02-0.90) and HLA-B Bw4 (HR=0.36, 95 CI=0.20-0.63) with better OS among FL patients. These results support a role for HLA in the prognosis of DLBCL and FL and represent a promising class of prognostic factors that warrants further evaluation. Copyright © 2011 Yani Lu et al.
Authors & Co-Authors
Lu, Yani
United States, Duarte
City of Hope National Med Center
Abdou, Amr M.
Egypt, Giza
National Research Centre
Cerhan, James R.
United States, Rochester
Mayo Medical School
Morton, Lindsay Mc Omber
United States, Rockville
National Cancer Institute Nci
Severson, Richard K.
United States, Detroit
Wayne State University
Davis, Scott
United States, Seattle
University of Washington
Cozen, Wendy
United States, Los Angeles
Usc Norris Comprehensive Cancer Center
Rothman, Nathaniel
United States, Rockville
National Cancer Institute Nci
Bernstein, Leslie R.
United States, Duarte
City of Hope National Med Center
Chanock, Stephen J.
United States, Rockville
National Cancer Institute Nci
Hartge, Patricia A.
United States, Rockville
National Cancer Institute Nci
Wang, Sophia S.
United States, Duarte
City of Hope National Med Center
Statistics
Citations: 15
Authors: 12
Affiliations: 7
Identifiers
Doi:
10.1100/2011/373876
e-ISSN:
1537744X
Research Areas
Cancer
Environmental
Genetics And Genomics
Study Design
Cross Sectional Study