Treatment of epidemic typhus

The authors describe their experience in the treatment of epidemic typhus with three drug regimes, chloramphenicol, doxycycline and trimethoprim-sulphamethoxazole, following a partly double-blind and partly random study. 65 patients were treated, and the conclusion was reached that trimethoprim- sulphamethoxazole was not indicated, that chloramphenicol and doxycycline were about equally effective, though doxycycline was preferred because of the simplicity of dosage and of the absence of side effects. © 1973, Oxford University Press. All rights resevered.