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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
A trial of a group a plus group c meningococcal polysaccharide-protein
Journal of Infectious Diseases, Volume 171, No. 3, Year 1995
Notification
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Description
The safety and immunogenicity of a group A plus group C meningococcal polysaccharide CRM197conjugate vaccine was evaluated in 304 8- to 10-week-old Gambian infants. Infants were immunized with one, two, or three doses of conjugate vaccine or with two doses of a meningococcal A plus C polysaccharide vaccine. The conjugate vaccine produced few systemic side effects, and local reactions were similar to those produced by the polysaccharide vaccine. Postvaccination group A meningococcal polysaccharide antibody levels, measured by ELISA, increased progressively after one, two, or three doses of conjugate vaccine. However, one dose of conjugate vaccine given at the age of 6 months induced a higher group C meningococcal antibody response than did two doses of conjugate vaccine given at 2 and 6 months. Two doses of conjugate vaccine induced higher levels of antibody than did two doses of polysaccharide vaccine. Thus, this new meningococcal conjugate vaccine proved to be safe and immunogenic. © 1995 The University of Chicago Press.
Authors & Co-Authors
Twumasi, Patrick A.
Gambia, Banjul
Medical Research Council Laboratories Gambia
United States, Atlanta
Centers for Disease Control and Prevention
United Kingdom, London
Royal Brompton Hospital
United States, Washington, D.c.
Howard University
United Kingdom, Birmingham
Heartlands Hospital
Kumah, Samuel
Gambia, Banjul
Medical Research Council Laboratories Gambia
United States, Atlanta
Centers for Disease Control and Prevention
United Kingdom, London
Royal Brompton Hospital
United States, Washington, D.c.
Howard University
United Kingdom, Birmingham
Heartlands Hospital
Leach, Amanda
Gambia, Banjul
Medical Research Council Laboratories Gambia
United States, Atlanta
Centers for Disease Control and Prevention
O’dempsey, Timothy J.D.
Gambia, Banjul
Medical Research Council Laboratories Gambia
United States, Atlanta
Centers for Disease Control and Prevention
United Kingdom, London
Royal Brompton Hospital
United States, Washington, D.c.
Howard University
United Kingdom, Birmingham
Heartlands Hospital
Ceesay, Serign Jawo
Gambia, Banjul
Medical Research Council Laboratories Gambia
United States, Atlanta
Centers for Disease Control and Prevention
Todd, Jim E.
Gambia, Banjul
Medical Research Council Laboratories Gambia
United States, Atlanta
Centers for Disease Control and Prevention
Broome, Claire V.
Gambia, Banjul
Medical Research Council Laboratories Gambia
United States, Atlanta
Centers for Disease Control and Prevention
Carlone, George M.
Gambia, Banjul
Medical Research Council Laboratories Gambia
United States, Atlanta
Centers for Disease Control and Prevention
Pais, Lorna B.
Gambia, Banjul
Medical Research Council Laboratories Gambia
United States, Atlanta
Centers for Disease Control and Prevention
Holder, Patricia F.
Gambia, Banjul
Medical Research Council Laboratories Gambia
United States, Atlanta
Centers for Disease Control and Prevention
Plikaytis, Brian D.
Gambia, Banjul
Medical Research Council Laboratories Gambia
United States, Atlanta
Centers for Disease Control and Prevention
Greenwood, Brian M.
Gambia, Banjul
Medical Research Council Laboratories Gambia
United States, Atlanta
Centers for Disease Control and Prevention
Statistics
Citations: 158
Authors: 12
Affiliations: 5
Identifiers
Doi:
10.1093/infdis/171.3.632
ISSN:
00221899
e-ISSN:
15376613