Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Characterization of HIV type 1 reverse transcriptase mutations in infants infected by mothers who received peripartum nevirapine prophylaxis in Jos, Nigeria
AIDS Research and Human Retroviruses, Volume 23, No. 12, Year 2007
Notification
URL copied to clipboard!
Description
This study was carried out to characterize HIV-1 reverse transcriptase (RT) mutations in vertically infected infants in Jos, Nigeria. DNA was extracted from peripheral blood mononuclear cells of 102 infants, aged 0 to 6 months, born to HIV-1-infected mothers who had received peripartum single-dose nevirapine prophylaxis. PCR-based diagnosis revealed that 14 infants (13.7%) were infected with HIV-1. Phylogenetic analyses of RT revealed wide viral diversity, with CRF02_AG, subtype G, subsubtype A3, CRF06_cpx, and a subtype D recombinant present in the population. Four of 13 (31%) infants had NNRTI resistance mutations - V179I (2 infants), Y181C, and V179E. Intriguingly, subtype G sequences did not have NNRTI mutations but rather carried a Q207N mutation, which may undergo negative selection under drug pressure. Our data suggest wide diversity for vertically transmitted HIV-1 viruses in Nigeria and highlight the potential significance of transmitting rare mutations in subtype G. © 2007 Mary Ann Liebert, Inc.
Authors & Co-Authors
Ojesina, Akinyemi I.
United States, Boston
Harvard T.h. Chan School of Public Health
Mullins, Christopher
United States, Boston
Harvard T.h. Chan School of Public Health
Imade, Godwin Eremwan
Nigeria, Jos
University of Jos
Samuels, Jay
United States, Boston
Harvard T.h. Chan School of Public Health
Sankalé, Jean Louis G.
United States, Boston
Harvard T.h. Chan School of Public Health
Pam, Sunday D.
Nigeria, Jos
University of Jos
Sagay, Solomon A.
Nigeria, Jos
University of Jos
Idoko, John Alechenu
Nigeria, Jos
University of Jos
Kanki, Phyllis Jean
United States, Boston
Harvard T.h. Chan School of Public Health
Statistics
Citations: 9
Authors: 9
Affiliations: 2
Identifiers
Doi:
10.1089/aid.2007.0064
ISSN:
08892229
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Study Locations
Nigeria