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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Foetal and childhood growth and asthma in adult life
Acta Paediatrica, International Journal of Paediatrics, Volume 102, No. 7, Year 2013
Notification
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Description
Aim Recent research suggests that asthma may originate through defects in the airway epithelium, acquired in utero, and an altered response to infections after birth. Here, we examine whether asthma in adult life is associated with reduced body size at birth and poor living conditions in childhood. Methods We studied 658 people taking medication for asthma in a cohort of 13 345 men and women born in Helsinki, Finland, during 1934-1944. Their body and placental size at birth, and their living conditions and growth in childhood, had been recorded. Results The odds ratios for asthma were 0.93 (95% CI 0.89-0.97, p = 0.001) per cm increase in birth length and 0.92 (0.89-0.96, p < 0.001) per cm increase in the length of placental surface. After allowing for size at birth, growth during childhood was unrelated to asthma. People who were born into families of low socio-economic status were at increased risk of later asthma. Conclusion Slow linear growth in utero, which could be a result of impaired placentation, increases the risk of later asthma. Slow linear growth may be associated with impaired development of the airways. Babies with impaired lung development born into families of low socio-economic status may be most vulnerable to the disease. © 2013 Foundation Acta Pædiatrica. Published by John Wiley & Sons Ltd.
Authors & Co-Authors
Barker, David J.P.
Unknown Affiliation
Osmond, Clive
Unknown Affiliation
Forsén, Tom J.
Unknown Affiliation
Thornburg, Kent L.
Unknown Affiliation
Kajantie, Eero O.
Unknown Affiliation
Eriksson, Johan Gunnar
Unknown Affiliation
Statistics
Citations: 44
Authors: 6
Affiliations: 11
Identifiers
Doi:
10.1111/apa.12257
ISSN:
08035253
e-ISSN:
16512227
Research Areas
Maternal And Child Health
Study Design
Cohort Study
Participants Gender
Male
Female