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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Rifamycin Lavage in the Treatment of Experimental Intra-Abdominal Infection
Journal of Surgical Research, Volume 155, No. 2, Year 2009
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Description
Hypothesis: Peritoneal lavage with rifamycin reduces the number of intraperitoneal bacteria and adhesions and improves the outcome of intra-abdominal infection (IAI). Material and methods: Experimental IAI was induced in Wistar rats. After 24 h, the animals underwent relaparotomy. A peritoneal fluid sample was obtained and lavage of the abdominal cavity was performed. Animals were randomly assigned to the three following groups: lavage with 0.9% sodium chloride solution (S group); lavage with rifamycin at the dose of 25 mg/kg (R25 group); and lavage with rifamycin at the dose of 12.5 mg/kg (R12.5 group). Mortality was recorded every 8 h for 7 d. All animals that died had a necropsy. Surviving rats were later sacrificed and also underwent a necropsy. At necropsy, intraperitoneal adhesions were noted and a peritoneal fluid sample was obtained for bacterial analysis. Results: Peritoneal lavage with rifamycin improved survival from 50% in the S group to 91.7 and 100% in the R25 group and R12.5 group, respectively. Adhesion formation was significantly reduced in the R25 group and R12.5 group compared with the S group (P ≤ 0.01 and P < 0.01, respectively). There was a greater reduction in bacterial counts in peritoneal fluid in the R25 group compared with the S group (P = 0.003) but there was no significant difference in the reduction of bacterial count between R25 group and R12.5 group. Conclusion: These results suggest that peritoneal lavage with rifamycin improves the outcome of IAI. © 2009 Elsevier Inc. All rights reserved.
Authors & Co-Authors
Jallouli, Mohamed
Tunisia, Sfax
Chu Hedi-chaker
Hakim, Ahmed
Tunisia, Sfax
Faculty of Medicine of Sfax
Znazen, Abir
Tunisia, Sfax
Chu Habib Bourguiba
Sahnoun, Zouheir
Tunisia, Sfax
Faculty of Medicine of Sfax
Kallel, Hatem
Tunisia, Sfax
Chu Habib Bourguiba
Zghal, Khaled M.
Tunisia, Sfax
Faculty of Medicine of Sfax
Hammami, Adenène
Tunisia, Sfax
Chu Habib Bourguiba
Mhiri, Riadh
Tunisia, Sfax
Chu Hedi-chaker
Statistics
Citations: 8
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1016/j.jss.2008.03.041
ISSN:
00224804
e-ISSN:
10958673