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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Depletion of regulatory T cells in HIV infection is associated with immune activation
Journal of Immunology, Volume 174, No. 7, Year 2005
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Description
Immune activation during chronic HIV infection is a strong clinical predictor of death and may mediate CD4+ T cell depletion. Regulatory T cells (Tregs) are CD4+CB25brightCD62Lhigh cells that actively down-regulate immune responses. We asked whether loss of Tregs during HIV infection mediates immune activation in a cross-sectional study of 81 HIV-positive Ugandan volunteers. We found that Treg number is strongly correlated with both CD4+ and CD8+ T cell activation. In multivariate modeling, this relationship between Treg depletion and CD4 + T cell activation was stronger than any other clinical factor examined, including viral load and absolute CD4 count. Tregs appear to decline at different rates compared with other CD4+ T cells, resulting in an increased regulator to helper ratio in many patients with advanced disease. We hypothesize that this skewing may contribute to T cell effector dysfunction. Our findings suggest Tregs are a major contributor to the immune activation observed during chronic HIV infection. Copyright © 2005 by The American Association of Immunologists, Inc.
Authors & Co-Authors
Eggena, Mark
United States, San Francisco
University of California, San Francisco
United States, Washington, D.c.
United States Department of Health and Human Services
Barugahare, Banson John
Uganda, Kampala
Joint Clinical Research Center Uganda
Jones, Norman G.
United States, Sacramento
California Department of Health Services
Okello, Martin
Uganda, Kampala
Joint Clinical Research Center Uganda
Mutalya, Steven
Uganda, Kampala
Joint Clinical Research Center Uganda
Kityo, Cissy Mutuluuza
Uganda, Kampala
Joint Clinical Research Center Uganda
Mugyenyi, Peter N.
Uganda, Kampala
Joint Clinical Research Center Uganda
Cao, Huyen L.
United States, Sacramento
California Department of Health Services
Statistics
Citations: 393
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.4049/jimmunol.174.7.4407
ISSN:
00221767
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study
Study Approach
Quantitative