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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Tumor exosomes inhibit differentiation of bone marrow dendritic cells
Journal of Immunology, Volume 178, No. 11, Year 2007
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Description
The production of exosomes by tumor cells has been implicated in tumor-associated immune suppression. In this study, we show that, in mice, exosomes produced by TS/A murine mammary tumor cells target CD11b+ myeloid precursors in the bone marrow (BM) in vivo, and that this is associated with an accumulation of myeloid precursors in the spleen. Moreover, we demonstrate that TS/A exosomes block the differentiation of murine myeloid precursor cells into dendritic cells (DC) in vitro. Addition of tumor exosomes at day 0 led to a significant block of differentiation into DC, whereas addition at later time points was less effective. Similarly, exosomes produced by human breast tumor cells inhibited the differentiation of human monocytes in vitro. The levels of IL-6 and phosphorylated Stat3 were elevated 12 h after the tumor exosome stimulation of murine myeloid precursors, and tumor exosomes were less effective in inhibiting differentiation of BM cells isolated from IL-6 knockout mice. Addition of a rIL-6 to the IL-6 knockout BM cell culture restored the tumor exosome-mediated inhibition of DC differentiation. These data suggest that tumor exosome-mediated induction of IL-6 plays a role in blocking BM DC differentiation. Copyright © 2007 by The American Association of Immunologists, Inc.
Authors & Co-Authors
Liu, Cunren
United States, Birmingham
Heersink School of Medicine
Su, Kaihong
United States, Birmingham
Heersink School of Medicine
Cong, Yingzi
United States, Birmingham
The University of Alabama at Birmingham
Kimberly, Robert P.
United States, Birmingham
Heersink School of Medicine
Grizzle, William E.
United States, Birmingham
The University of Alabama at Birmingham
Falkson, Carla Isadora
United States, Birmingham
The University of Alabama at Birmingham
Statistics
Citations: 399
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.4049/jimmunol.178.11.6867
ISSN:
00221767
Research Areas
Cancer