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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Which health-related quality of life score? A comparison of alternative utility measures in patients with Type 2 diabetes in the ADVANCE trial
Health and Quality of Life Outcomes, Volume 5, Article 21, Year 2007
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Description
Background: Diabetes has a high burden of illness both in life years lost and in disability through related co-morbidities. Accurate assessment of the non-mortality burden requires appropriate health-related quality of life and summary utility measures of which there are several contenders. The study aimed to measure the impact of diabetes on various health-related quality of life domains, and compare several summary utility measures. Methods: In the ADVANCE (Action in Diabetes and Vascular Disease: Preterax and Diamicron MR Controlled Evaluation) study, 978 Australian patients with Type 2 diabetes completed two health-related quality of life questionnaires at baseline: the EQ-5D and the SF-36v2, from which nine summary utility measures were calculated, and compared. The algorithms were grouped into four classes: (i) based on the EQ-5D; (ii) using fewer items than those in the SF-12 (iii) using the items in the SF-12; and (iv) using all items of the SF-36. Results: Overall health-related quality of life of the subjects was good (mean utility ranged from 0.68 (±0.08) to 0.85(±0.14) over the nine utility measures) and comparable to patients without diabetes. Summary indices were well correlated with each other (r = 0.76 to 0.99), and showed lower health-related quality of life in patients with major diabetes-related events such as stroke or myocardial infarction. Despite the smaller number of items used in the scoring of the EQ-5D, it generally performed at least as well as SF-36 based methods. However, all utility measures had some limitation such as limited range or ceiling effects. Conclusion: The summary utility measures showed good agreement, and showed good discrimination between major and minor health state changes. However, EQ-5D based measures performed as well and are generally simpler to use. © 2007 Glasziou et al; licensee BioMed Central Ltd.
Authors & Co-Authors
Glasziou, Paul
United Kingdom, London
Cancer Research uk
Beller, Elaine Margaret
Australia, Sydney
The University of Sydney
Chalmers, John P.
Unknown Affiliation
Macmahon, Stephen W.
Unknown Affiliation
Cooper, Mark Emmanuel
Unknown Affiliation
Grobbee, Diederick E Egbertus
Unknown Affiliation
Harrap, Stephen B.
Unknown Affiliation
Heller, Simon R.
Unknown Affiliation
Liu, Lisheng Strategies For Ischemic Syndromes Registry
Unknown Affiliation
Mancia, Giuseppe
Unknown Affiliation
Marre, Michel
Unknown Affiliation
Mogensen, Carl Erik
Unknown Affiliation
Neal, Bruce Charles
Unknown Affiliation
Patel, Anushka A.
Unknown Affiliation
Poulter, Neil R.
Unknown Affiliation
Rodgers, Anthony J.
Unknown Affiliation
Woodward, Mark A.
Unknown Affiliation
Collins, Rory
Unknown Affiliation
Holman, Rury R.
Unknown Affiliation
Sleight, Peter J.
Unknown Affiliation
Fulcher, Greg R.
Unknown Affiliation
Mitchell, Paul G.
Unknown Affiliation
Joshi, Rohina M.
Unknown Affiliation
Kengne, Andre-Pascal Pascal
Unknown Affiliation
Monaghan, Helen
Unknown Affiliation
Perkovic, Vlado
Unknown Affiliation
Statistics
Citations: 112
Authors: 26
Affiliations: 3
Identifiers
Doi:
10.1186/1477-7525-5-21
ISSN:
14777525
Research Areas
Disability
Noncommunicable Diseases