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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Type 2 diabetes mellitus in people with severe mental illness: inequalities by ethnicity and age. Cross-sectional analysis of 588 408 records from the UK
Diabetic Medicine, Volume 34, No. 7, Year 2017
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Description
Aims: To investigate whether the association of severe mental illness with Type 2 diabetes varies by ethnicity and age. Methods: We conducted a cross-sectional analysis of data from an ethnically diverse sample of 588 408 individuals aged ≥18 years, registered to 98% of general practices (primary care) in London, UK. The outcome of interest was prevalent Type 2 diabetes. Results: Relative to people without severe mental illness, the relative risk of Type 2 diabetes in people with severe mental illness was greatest in the youngest age groups. In the white British group the relative risks were 9.99 (95% CI 5.34, 18.69) in those aged 18–34 years, 2.89 (95% CI 2.43, 3.45) in those aged 35–54 years and 1.16 (95% CI 1.04, 1.30) in those aged ≥55 years, with similar trends across all ethnic minority groups. Additional adjustment for anti-psychotic prescriptions only marginally attenuated the associations. Assessment of estimated prevalence of Type 2 diabetes in severe mental illness by ethnicity (absolute measures of effect) indicated that the association between severe mental illness and Type 2 diabetes was more marked in ethnic minorities than in the white British group with severe mental illness, especially for Indian, Pakistani and Bangladeshi individuals with severe mental illness. Conclusions: The relative risk of Type 2 diabetes is elevated in younger populations. Most associations persisted despite adjustment for anti-psychotic prescriptions. Ethnic minority groups had a higher prevalence of Type 2 diabetes in the presence of severe mental illness. Future research and policy, particularly with respect to screening and clinical care for Type 2 diabetes in populations with severe mental illness, should take these findings into account. © 2016 The Authors. Diabetic Medicine published by John Wiley & Sons Ltd on behalf of Diabetes UK.
Authors & Co-Authors
Das-Munshi, Jayati
United Kingdom, London
King's College London
Ashworth, Mark
United Kingdom, London
King's College London
Dewey, Michael E.
United Kingdom, London
King's College London
Gaughran, Fiona P.
United Kingdom, London
South London and Maudsley Nhs Foundation Trust
Hull, Sally A.H.
United Kingdom, London
Barts and the London School of Medicine and Dentistry
Morgan, Craig
United Kingdom, London
King's College London
Nazroo, James Y.
United Kingdom, Manchester
The University of Manchester
Petersen, Inge
United Kingdom, London
University College London
Stewart, Robert J.
United Kingdom, London
King's College London
Thornicroft, Graham
United Kingdom, London
King's College London
Prince, Martin J.
United Kingdom, London
King's College London
Statistics
Citations: 34
Authors: 11
Affiliations: 5
Identifiers
Doi:
10.1111/dme.13298
ISSN:
07423071
Research Areas
Health System And Policy
Mental Health
Noncommunicable Diseases
Study Design
Cross Sectional Study