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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Candida auris Clinical Isolates Associated with Outbreak in Neonatal Unit of Tertiary Academic Hospital, South Africa
Emerging Infectious Diseases, Volume 29, No. 10, Year 2023
Notification
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Description
Candida auris was first detected at a university-affiliated hospital in Johannesburg, South Africa, in 2009. We used whole-genome sequencing to describe the molecular epidemiology of C. auris in the same hospital during 2016-2020; the neonatal unit had a persistent outbreak beginning in June 2019. Of 287 cases with culture-confirmed C. auris infection identified through laboratory surveillance, 207 (72%) had viable isolates and 188 (66%) were processed for whole-genome sequencing. Clade III (118/188, 63%) and IV (70/188, 37%) isolates co-circulated in the hospital. All 181/188 isolates that had a fluconazole MIC >32 µg/mL had ERG11 mutations; clade III isolates had VF125AL substitutions, and clade IV isolates had K177R/N335S/E343D substitutions. Dominated by clade III, the neonatal unit outbreak accounted for 32% (91/287) of all cases during the study period. The outbreak may have originated through transmission from infected or colonized patients, colonized healthcare workers, or contaminated equipment/environment. © 2023 Centers for Disease Control and Prevention (CDC). All rights reserved.
Authors & Co-Authors
Kekana, Dikeledi
South Africa, Johannesburg
National Institute for Communicable Diseases
South Africa, Johannesburg
University of the Witwatersrand
Naicker, Serisha Devi
South Africa, Johannesburg
National Institute for Communicable Diseases
Shuping, Liliwe L.
South Africa, Johannesburg
National Institute for Communicable Diseases
Velaphi, Sithembiso Christopher
South Africa, Johannesburg
University of the Witwatersrand
South Africa, Johannesburg
Chris Hani Baragwanath Hospital
Nakwa, Firdose Lambey
South Africa, Johannesburg
University of the Witwatersrand
South Africa, Johannesburg
Chris Hani Baragwanath Hospital
Wadula, Jeannette
South Africa, Johannesburg
University of the Witwatersrand
South Africa, Johannesburg
Chris Hani Baragwanath Hospital
Govender, Nelesh P.
South Africa, Johannesburg
National Institute for Communicable Diseases
South Africa, Johannesburg
University of the Witwatersrand
South Africa, Cape Town
University of Cape Town
United Kingdom, Exeter
University of Exeter
Black, John M.
Unknown Affiliation
Pearce, Vanessa
Unknown Affiliation
Moncho, Masego
Unknown Affiliation
Maloba, Motlatji
Unknown Affiliation
Hoosen, Anwar Ahmed
Unknown Affiliation
Verwey, Charl
Unknown Affiliation
Menezes, Colin Nigel
Unknown Affiliation
Moore, David Paul
Unknown Affiliation
Reubenson, Gary
Unknown Affiliation
Ntlemo, Grace
Unknown Affiliation
Nel, Jeremy Stephen
Unknown Affiliation
Nchabeleng, Maphoshane J.
Unknown Affiliation
Tsitsi, Merika
Unknown Affiliation
Moshe, Mamokgethi
Unknown Affiliation
Said, Mohamed
Unknown Affiliation
Du Plessis, Nicolette Marie
Unknown Affiliation
Chomba, Rispah N.
Unknown Affiliation
Stacey, Sarah Lynn
Unknown Affiliation
Avenant, T.
Unknown Affiliation
Nana, Trusha
Unknown Affiliation
Chibabhai, Vindana
Unknown Affiliation
Maharj, Adhil
Unknown Affiliation
Wilson, Douglas P.K.
Unknown Affiliation
Naby, Fathima
Unknown Affiliation
Dawood, Haiima
Unknown Affiliation
Swe Swe-Han, Khine Swe Swe
Unknown Affiliation
Sookan, Lisha
Unknown Affiliation
Dlamini, Nomonde Ritta
Unknown Affiliation
Ramjathan, Praksha
Unknown Affiliation
Mahabeer, Prasha
Unknown Affiliation
Bhola, Prathna
Unknown Affiliation
Naidoo, Romola
Unknown Affiliation
Haffejee, Sumayya
Unknown Affiliation
Sirkar, Surendra
Unknown Affiliation
Ramkillawan, Yeishna
Unknown Affiliation
Hamese, Ken
Unknown Affiliation
Sibiya, Ngoaka
Unknown Affiliation
Mangena, Phetho
Unknown Affiliation
Lekalakala, R. M.
Unknown Affiliation
Hoyland, Greta
Unknown Affiliation
Ntuli, Sindi
Unknown Affiliation
Jooste, Pieter L.
Unknown Affiliation
Variava, Ebrahim
Unknown Affiliation
Khantsi, Ignatius
Unknown Affiliation
Mekgoe, Omphile
Unknown Affiliation
Brink, Adrian John
Unknown Affiliation
Prentice, Elizabeth
Unknown Affiliation
Reddy, Kessendri
Unknown Affiliation
Whitelaw, Andrew C.
Unknown Affiliation
Hoosien, Ebrahim
Unknown Affiliation
Zietsman, Inge L.
Unknown Affiliation
Marshall, Terry
Unknown Affiliation
Poswa, Xoliswa
Unknown Affiliation
Govind, Chetna N.
Unknown Affiliation
Smit, Juanita
Unknown Affiliation
Pillay, Keshree
Unknown Affiliation
Seetharam, Sharona
Unknown Affiliation
Howell, Victoria
Unknown Affiliation
Samuel, Catherine Mary
Unknown Affiliation
Senekal, Marthinus
Unknown Affiliation
Dreyer, Andries William
Unknown Affiliation
Marcus, Louis
Unknown Affiliation
Lowman, Warren
Unknown Affiliation
von Gottberg, Anne M.
Unknown Affiliation
Smith, Anthony Marius
Unknown Affiliation
Mathunjwa, Azwifarwi
Unknown Affiliation
Moodley, Bhavani
Unknown Affiliation
D'Abreu, Cecilia
Unknown Affiliation
Miller, Cecilia
Unknown Affiliation
Cohen, Cheryl D.
Unknown Affiliation
Ismail, Farzana
Unknown Affiliation
Moultrie, Harry
Unknown Affiliation
Ismail, Husna
Unknown Affiliation
Weyer, Jacqueline
Unknown Affiliation
Kleynhans, Jackie
Unknown Affiliation
Rossouw, Jenny
Unknown Affiliation
Frean, John Andrew
Unknown Affiliation
Ebonwu, Joy I.
Unknown Affiliation
Mwansa-Kambafwile, Judith R.M.
Unknown Affiliation
Thomas, Juno
Unknown Affiliation
Bishop, Kate
Unknown Affiliation
McCarthy, Kerrigan M.
Unknown Affiliation
de Gouveia, Linda D.
Unknown Affiliation
Erasmus, Linda Kathleen
Unknown Affiliation
Morris, Lynn
Unknown Affiliation
Blumberg, Lucille Hellen
Unknown Affiliation
Smith, Marshagne
Unknown Affiliation
Makgoba, Martha
Unknown Affiliation
Groome, Michelle J.
Unknown Affiliation
Du Plessis, Mignon D.
Unknown Affiliation
Ngomane, Mimmy
Unknown Affiliation
Manaka, Mokupi
Unknown Affiliation
Moremi, Myra
Unknown Affiliation
Ismail, Nazir Ahmed
Unknown Affiliation
Govender, Nelesh P.
Unknown Affiliation
Legare, Neo
Unknown Affiliation
Page, Nicola A.
Unknown Affiliation
Hoho, Nombulelo
Unknown Affiliation
Perovic, Olga
Unknown Affiliation
Sekwadi, Phuti G.
Unknown Affiliation
Magobo, Rindidzani E.
Unknown Affiliation
Mashau, Rudzani C.
Unknown Affiliation
Mpembe, Ruth S.
Unknown Affiliation
Walaza, Sibongile
Unknown Affiliation
Dlamini, Siyanda
Unknown Affiliation
Meiring, Susan T.
Unknown Affiliation
Lebaka, Tiisetso
Unknown Affiliation
Quan, Vanessa Cecilia
Unknown Affiliation
Ngubane, Wendy
Unknown Affiliation
Statistics
Authors: 116
Affiliations: 5
Identifiers
Doi:
10.3201/eid2910.230181
ISSN:
10806040
Research Areas
Health System And Policy
Maternal And Child Health
Study Locations
South Africa