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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
A crowd of BashTheBug volunteers reproducibly and accurately measure the minimum inhibitory concentrations of 13 antitubercular drugs from photographs of 96-well broth microdilution plates
eLife, Volume 11, Article e75046, Year 2022
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Description
Tuberculosis is a respiratory disease that is treatable with antibiotics. An increasing prevalence of resistance means that to ensure a good treatment outcome it is desirable to test the susceptibility of each infection to different antibiotics. Conventionally this is done by culturing a clinical sample and then exposing aliquots to a panel of antibiotics, Using 96-well broth micro dilution plates with each well containing a lyophilised predetermined amount of an antibiotic is a convenient and cost-effective way to measure the MICs of several drugs at once for a clinical sample. Although accurate, this is still an expensive and slow process that requires highlyskilled and experienced laboratory scientists. Here we show that, through the BashTheBug project hosted on the Zooniverse citizen science platform, a crowd of volunteers can reproducibly and accurately determine the MICs for 13 drugs and that simply taking the median or mode of 11-17 independent classifications is sufficient. There is therefore a potential role for crowds to support (but not supplant) the role of experts in antibiotic susceptibility testing. © 2022, eLife Sciences Publications Ltd. All rights reserved.
Authors & Co-Authors
Fowler, Philip William
United Kingdom, Oxford
University of Oxford
Wright, Carla
United Kingdom, Oxford
University of Oxford
Spiers, Helen
United Kingdom, Oxford
University of Oxford
United Kingdom, London
The Francis Crick Institute
Zhu, Tingting
United Kingdom, Oxford
University of Oxford
Baeten, Elisabeth M.L.
United Kingdom, Oxford
University of Oxford
Hoosdally, Sarah J.
United Kingdom, Oxford
University of Oxford
Cruz, Ana Lúıza Gibertoni
United Kingdom, Oxford
University of Oxford
Roohi, Aysha
United Kingdom, Oxford
University of Oxford
Kouchaki, Samaneh
United Kingdom, Oxford
University of Oxford
United Kingdom, Guildford
University of Surrey
Walker, Timothy M.
United Kingdom, Oxford
University of Oxford
Viet Nam, Ho Chi Minh City
Oxford University Clinical Research Unit
Peto, Timothy E.A.
United Kingdom, Oxford
University of Oxford
Miller, Grant R.M.
United Kingdom, Oxford
University of Oxford
Lintott, Chris J.
United Kingdom, Oxford
University of Oxford
Clifton, David Andrew
United Kingdom, Oxford
University of Oxford
Crook, Derrick W.
United Kingdom, Oxford
University of Oxford
Walker, Ann Sarah
United Kingdom, Oxford
University of Oxford
Barilar, Ivan
Germany, Borstel
Forschungszentrum Borstel - Zentrum Für Medizin Und Biowissenschaften
Battaglia, Simone
Italy, Milan
Irccs Ospedale San Raffaele
Borroni, Emanuele
Italy, Milan
Irccs Ospedale San Raffaele
Brandão, Angela Pires
Brazil, Rio de Janeiro
Fundacao Oswaldo Cruz
Brazil, Cerqueira Cesar
Instituto Adolfo Lutz
Brankin, Alice E.
United Kingdom, Oxford
University of Oxford
Cabibbe, Andrea Maurizio
Italy, Milan
Irccs Ospedale San Raffaele
Carter, Joshua James
United States, Stanford
Stanford University School of Medicine
Chetty, Darren
South Africa, Durban
Africa Health Research Institute
Cirillo, D. M.
Italy, Milan
Irccs Ospedale San Raffaele
Claxton, Pauline M.
Unknown Affiliation
Clifton, David A.
United Kingdom, Oxford
University of Oxford
Cohen, Ted
United States, New Haven
Yale University
Coronel, Jorge E.
Peru, Lima
Universidad Peruana Cayetano Heredia
Dreyer, Viola
Germany, Borstel
Forschungszentrum Borstel - Zentrum Für Medizin Und Biowissenschaften
Earle, Sarah G.
United Kingdom, Oxford
University of Oxford
Escuyer, Vincent E.
United States, Albany
New York State Department of Health
Ferrazoli, Lucilaine
Brazil, Cerqueira Cesar
Instituto Adolfo Lutz
Gao, George Fu
China, Beijing
Chinese Center for Disease Control and Prevention
Gardy, Jennifer L.
Unknown Affiliation
Gharbia, Saheer E.
United Kingdom, London
Uk Health Security Agency
Ghisi, Kelen Teixeira
Brazil, Cerqueira Cesar
Instituto Adolfo Lutz
Ghodousi, Arash
Italy, Milan
Irccs Ospedale San Raffaele
Italy, Milan
Università Vita-salute San Raffaele
Grandjean, Louis
United Kingdom, London
University College London
Grazian, Clara
Australia, Sydney
Unsw Sydney
Groenheit, Ramona
Sweden, Solna
Public Health Agency of Sweden
Guthrie, Jennifer L.
Canada, Vancouver
The University of British Columbia
Canada, Toronto
Public Health Ontario
He, Wencong
China, Beijing
Chinese Center for Disease Control and Prevention
Hoffmann, Harald
Unknown Affiliation
Hoosdally, Sarah Jayne
United Kingdom, Oxford
University of Oxford
Martinhunt, M.
United Kingdom, Oxford
University of Oxford
United Kingdom, Hinxton
Embl’s European Bioinformatics Institute
Iqbal, Zamin
United Kingdom, Hinxton
Embl’s European Bioinformatics Institute
Ismail, Nazir Ahmed
South Africa, Johannesburg
National Institute for Communicable Diseases
Jarrett, Lisa
United Kingdom, London
Uk Health Security Agency
Joseph, Lavania
South Africa, Johannesburg
National Institute for Communicable Diseases
Jou, Ruwen
Taiwan, Taipei
Taiwan Centers for Disease Control
Kambli, Priti
India, Mumbai
P.d. Hinduja National Hospital and Medical Research Centre
Khot, Rukhsar
India, Mumbai
P.d. Hinduja National Hospital and Medical Research Centre
Knaggs, Jeff
United Kingdom, Oxford
University of Oxford
United Kingdom, Hinxton
Embl’s European Bioinformatics Institute
Koch, Anastasia Sideris
South Africa, Cape Town
University of Cape Town
Kohlerschmidt, Donna J.
United States, Albany
New York State Department of Health
Lachapelle, Alexander S.
United Kingdom, Oxford
University of Oxford
Lalvani, Ajit
United Kingdom, London
Imperial College London
Grandjean-Lapierre, Simon
Canada, Montreal
University of Montreal
Laurenson, Ian F.
Unknown Affiliation
Letcher, Brice
United Kingdom, Hinxton
Embl’s European Bioinformatics Institute
Lin, Wanhsuan
Taiwan, Taipei
Taiwan Centers for Disease Control
Liu, Chunfa
China, Beijing
Chinese Center for Disease Control and Prevention
Liu, Dongxin
China, Beijing
Chinese Center for Disease Control and Prevention
Malone, Kerri Marie
United Kingdom, Hinxton
Embl’s European Bioinformatics Institute
Mandal, Ayan
India, Mumbai
The Foundation for Medical Research India
Mansjö, Mikael
Sweden, Solna
Public Health Agency of Sweden
Matias, Daniela
United Kingdom, London
Uk Health Security Agency
Meintjes, Graeme Ayton
South Africa, Cape Town
University of Cape Town
Mendes, Flávia De Freitas
Brazil, Cerqueira Cesar
Instituto Adolfo Lutz
Merker, Matthias
Germany, Borstel
Forschungszentrum Borstel - Zentrum Für Medizin Und Biowissenschaften
Mihalic, Marina
Unknown Affiliation
Millard, James Daniel
South Africa, Durban
Africa Health Research Institute
Miotto, Paolo
Italy, Milan
Irccs Ospedale San Raffaele
Mistry, Nerges Furdoon
India, Mumbai
The Foundation for Medical Research India
Moore, David A.J.
Peru, Lima
Universidad Peruana Cayetano Heredia
United Kingdom, London
London School of Hygiene & Tropical Medicine
Musser, Kimberlee Aruda
United States, Albany
New York State Department of Health
Ngcamu, Dumisani
South Africa, Johannesburg
National Institute for Communicable Diseases
Nhung, Hoang Ngoc
Viet Nam, Ho Chi Minh City
Oxford University Clinical Research Unit
Niemann, Stefan
Germany, Borstel
Forschungszentrum Borstel - Zentrum Für Medizin Und Biowissenschaften
Germany, Hamburg
German Center for Infection Research Dzif
Nilgiriwala, Kayzad Soli
India, Mumbai
The Foundation for Medical Research India
Nimmo, Camus
United Kingdom, London
University College London
O’Donnell, Max R.
United States, New York
Columbia University
Okozi, Nana
South Africa, Johannesburg
National Institute for Communicable Diseases
de Oliveira, Rosângela Siqueira
Brazil, Cerqueira Cesar
Instituto Adolfo Lutz
Omar, Shaheed Vally
South Africa, Johannesburg
National Institute for Communicable Diseases
Paton, Nicholas Iain
Singapore, Singapore City
National University of Singapore
Pinhata, Juliana Maira Watanabe
Brazil, Cerqueira Cesar
Instituto Adolfo Lutz
Plesnik, Sara
Unknown Affiliation
Puyén, Zully M.
Peru, Lima
Instituto Nacional de Salud, Lima
Rabodoarivelo, Marie Sylvianne
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Rakotosamimanana, Niaina
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Rancoita, Paola M.V.
Italy, Milan
Università Vita-salute San Raffaele
Rathod, Priti
United Kingdom, London
Uk Health Security Agency
Robinson, Esther R.
United Kingdom, London
Uk Health Security Agency
Rodger, Gillian
United Kingdom, Oxford
University of Oxford
Rodrigues, Camilla S.
India, Mumbai
P.d. Hinduja National Hospital and Medical Research Centre
Rodwell, Timothy C.
Switzerland, Geneva
Find
United States, La Jolla
University of California, San Diego
Santos-Lázaro, David
Peru, Lima
Instituto Nacional de Salud, Lima
Shah, Sanchi
India, Mumbai
The Foundation for Medical Research India
Kohl, Thomas Andreas
Germany, Borstel
Forschungszentrum Borstel - Zentrum Für Medizin Und Biowissenschaften
Smith, Grace E.
United Kingdom, London
Uk Health Security Agency
Solano, Walter
Peru, Lima
Universidad Peruana Cayetano Heredia
Spitaleri, Andrea
Italy, Milan
Irccs Ospedale San Raffaele
Italy, Milan
Università Vita-salute San Raffaele
Supply, Philip
France, Lille
Institut Pasteur de Lille
Steyn, Adrie J.C.
South Africa, Durban
Africa Health Research Institute
Surve, Utkarsha
India, Mumbai
P.d. Hinduja National Hospital and Medical Research Centre
Tahseen, Sabira
Pakistan, Islamabad
National tb Reference Laboratory
Thuong, Nguyen Thuy
Viet Nam, Ho Chi Minh City
Oxford University Clinical Research Unit
Thwaites, Guy E.
United Kingdom, Oxford
University of Oxford
Viet Nam, Ho Chi Minh City
Oxford University Clinical Research Unit
Todt, Katharina
Unknown Affiliation
Trovato, A.
Italy, Milan
Irccs Ospedale San Raffaele
Utpatel, Christian
Germany, Borstel
Forschungszentrum Borstel - Zentrum Für Medizin Und Biowissenschaften
van Rie, Annelies
Belgium, Antwerpen
Universiteit Antwerpen
Walker, Anne Sarah
United Kingdom, Oxford
University of Oxford
Warren, Robin Mark
South Africa, Stellenbosch
Stellenbosch University
Werngren, Jim
Sweden, Solna
Public Health Agency of Sweden
Wijkander, Maria
Sweden, Solna
Public Health Agency of Sweden
Wilkinson, Robert John
United Kingdom, London
Imperial College London
South Africa, Cape Town
Wellcome Centre for Infectious Diseases Research in Africa
United Kingdom, London
The Francis Crick Institute
Wilson, Daniel J.
United Kingdom, Oxford
University of Oxford
Wintringer, Penelope
United Kingdom, Hinxton
Embl’s European Bioinformatics Institute
Yang, Yang
United Kingdom, Oxford
University of Oxford
Zhu, Baoli
China, Beijing
Chinese Academy of Sciences
Statistics
Citations: 6
Authors: 123
Affiliations: 44
Identifiers
Doi:
10.7554/eLife.75046
ISSN:
2050084X
Study Design
Cross Sectional Study