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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Evaluation of cardiac functions with Doppler echocardiography in children with Down syndrome and anatomically normal heart
Cardiology in the Young, Volume 23, No. 2, Year 2013
Notification
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Description
Objective To study the cardiac functions in Down syndrome children who did not have structural cardiac lesion by conventional and tissue Doppler echocardiography. Materials and methods A total of 85 children with Down syndrome without anatomic heart disease and 50 normal control children were subjected to the assessment of right and left ventricular functions by both two-dimensional and tissue Doppler echocardiography. Results Children with Down syndrome had significantly higher left ventricular ejection fraction detected by two-dimensional echocardiography and left ventricular diastolic dysfunction detected by tissue Doppler than observed in the controls. In addition, children with Down syndrome also had right ventricular systolic and diastolic dysfunctions. Children with Down syndrome had significantly higher pulmonary artery systolic pressure than the control children. There was no significant difference in the cardiac functions between children with non-disjunction Down syndrome and those with the translocation type. Conclusion Despite an apparently normal heart, children with Down syndrome may have silent disturbed cardiac functions, which may be detected by two-dimensional or tissue Doppler echocardiography. This may have an important clinical implication, especially before involving Down syndrome children in surgery or strenuous exercise. © 2012 Cambridge University Press.
Authors & Co-Authors
Al-Beltagi, Mohammed
Egypt, Tanta
Faculty of Medicine
Serag, Amany R.
Egypt, Shibin el Kom
Menoufia University Faculty of Medicine
Hefidah, Mohammed M.
Egypt, Tanta
Faculty of Medicine
Mabrouk, Maaly Mohammad
Egypt, Tanta
Faculty of Medicine
Statistics
Citations: 27
Authors: 4
Affiliations: 2
Identifiers
Doi:
10.1017/S1047951112000613
ISSN:
10479511
e-ISSN:
14671107
Research Areas
Health System And Policy
Maternal And Child Health
Noncommunicable Diseases