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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Molecularly cloned SHIV-1157ipd3N4: A highly replication-competent, mucosally transmissible R5 simian-human immunodeficiency virus encoding HIV clade C env
Journal of Virology, Volume 80, No. 17, Year 2006
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Description
Human immunodeficiency virus type 1 (HIV-1) clade C causes >50% of all HIV infections worldwide, and an estimated 90% of all transmissions occur mucosally with R5 strains. A pathogenic R5 simian-human immunodeficiency virus (SHIV) encoding HIV clade C env is highly desirable to evaluate candidate AIDS vaccines in nonhuman primates. To this end, we generated SHIV-1157i, a molecular clone from a Zambian infant isolate that carries HIV clade C env. SHIV-1157i was adapted by serial passage in five monkeys, three of which developed peripheral CD4+ T-cell depletion. After the first inoculated monkey developed AIDS at week 137 postinoculation, transfer of its infected blood to a naive animal induced memory T-cell depletion and thrombocytopenia within 3 months in the recipient. In parallel, genomic DNA from the blood donor was amplified to generate the late proviral clone SHIV-1157ipd3. To increase the replicative capacity of SHIV-1157ipd3, an extra NF-κB binding site was engineered into its 3′ long terminal repeat, giving rise to SHIV-1157ipd3N4. This virus was exclusively R5 tropic and replicated more potently in rhesus peripheral blood mononuclear cells than SHIV-1157ipd3 in the presence of tumor necrosis factor alpha. Rhesus macaques of Indian and Chinese origin were next inoculated intrarectally with SHIV-1157ipd3N4; this virus replicated vigorously in both sets of monkeys. We conclude that SHIV-1157ipd3N4 is a highly replication-competent, mucosally transmissible R5 SHIV that represents a valuable tool to test candidate AIDS vaccines targeting HIV-1 clade C Env. Copyright © 2006, American Society for Microbiology. All Rights Reserved.
Authors & Co-Authors
Song, Ruijiang
United States, Boston
Dana-farber Cancer Institute
United States, Boston
Harvard Medical School
Chenine, Agnès Laurence
United States, Boston
Dana-farber Cancer Institute
United States, Boston
Harvard Medical School
Rasmussen, Robert A.
United States, Boston
Dana-farber Cancer Institute
United States, Boston
Harvard Medical School
Ruprecht, C. R.
United States, Boston
Dana-farber Cancer Institute
Mirshahidi, S.
United States, Boston
Dana-farber Cancer Institute
United States, Boston
Harvard Medical School
Grisson, Ricky D.
United States, Boston
Dana-farber Cancer Institute
United States, Boston
Harvard Medical School
Xu, Weidong
United States, Boston
Dana-farber Cancer Institute
United States, Boston
Harvard Medical School
Whitney, James B.
United States, Boston
Dana-farber Cancer Institute
United States, Boston
Harvard Medical School
Goins, L. M.
United States, Boston
Dana-farber Cancer Institute
United States, Boston
Harvard Medical School
Ong, Helena
United States, Boston
Dana-farber Cancer Institute
Li, Peilin
United States, Boston
Dana-farber Cancer Institute
United States, Boston
Harvard Medical School
Shai-Kobiler, E.
United States, Boston
Dana-farber Cancer Institute
United States, Boston
Harvard Medical School
Wang, T.
United States, Boston
Dana-farber Cancer Institute
United States, Boston
Harvard Medical School
McCann, C. M.
United States, Boston
Dana-farber Cancer Institute
United States, Boston
Harvard Medical School
Zhang, Hong Y.
United States, Lincoln
School of Biological Sciences
Wood, Charles
United States, Lincoln
School of Biological Sciences
Kankasa, Chipepo
Zambia, Lusaka
University Teaching Hospital Lusaka
Secor, William Evan
United States, Atlanta
Centers for Disease Control and Prevention
McClure, Harold M.
United States, Atlanta
Emory University
Strobert, E.
United States, Atlanta
Emory University
Else, James G.
United States, Atlanta
Emory University
Ruprecht, Ruth M.
United States, Boston
Dana-farber Cancer Institute
United States, Boston
Harvard Medical School
Statistics
Citations: 158
Authors: 22
Affiliations: 6
Identifiers
Doi:
10.1128/JVI.00558-06
ISSN:
0022538X
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases
Maternal And Child Health