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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Serum interleukin-4 and total immunoglobulin e in nonatopic alopecia areata patients and HLA-DRB1 typing
Dermatology Research and Practice, Volume 2010, No. 1, Article 503587, Year 2010
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Description
Background. Interleukin-4 (IL-4), a Thcytokine, can stimulate immunoglobulin E (IgE) transcription. No previous studies evaluated the genetic mechanisms in nonatopic AA patients with elevated serum IgE. Objective. To compare serum IL-4 and total IgE levels between Egyptian nonatopic AA patients and healthy subjects and to investigate a possible relation to HLA-DRB1 alleles. Results. Serum IL-4 and total IgE were measured by ELISA in 40 controls and 54 nonatopic AA patients. Patients' HLA-DRB1 typing by sequence specific oligonucleotide probe technique was compared to normal Egyptian population. We found significantly elevated serum IL-4 and total IgE in AA patients (particularly alopecia universalis, AU, and chronic patients) (P<.01). HLA-DRB1*11 is a general susceptibility/chronicity allele. DRB1*13 is a protective allele. DRB1*01 and DRB1*07 are linked to chronicity. Localized AA showed decreased DRB1*03 and DRB1*07. Extensive forms showed increased DRB1*08 and decreased DRB1*04. Elevated IL4 and IgE were observed in patients with DRB1*07 and DRB1*11 not DRB1*04. Conclusion. Serum IL-4 and IgE are elevated in nonatopic AA patients, particularly AU and chronic disease. Relevant susceptibility, chronicity, and severity HLADRB1 alleles may have a role in determining type, magnitude, and duration of immune response in AA favouring increased IL4 and IgE. © 2010 Enas A. S. Attia et al.
Authors & Co-Authors
Attia, Enas A.S.
Egypt, Cairo
Faculty of Medicine - Ain Shams University
El-Shennawy, Dina A.
Egypt, Cairo
Faculty of Medicine - Ain Shams University
Sefin, Ashraf
Egypt, Cairo
Faculty of Medicine - Ain Shams University
Statistics
Citations: 39
Authors: 3
Affiliations: 1
Identifiers
Doi:
10.1155/2010/503587
e-ISSN:
16876113
Research Areas
Genetics And Genomics
Study Design
Cross Sectional Study