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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Fluctuation of abundance and Lassa virus prevalence in Mastomys natalensis in Guinea, West Africa
Vector-Borne and Zoonotic Diseases, Volume 7, No. 2, Year 2007
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Description
Based on empiric surveillance data, the incidence of human Lassa fever (LF) cases in Guinea and other West African countries has been reported to increase during the dry season compared to the rainy season. To investigate possible links with the ecology of the rodent reservoir of the virus, we conducted a 2-year longitudinal survey of Mastomys natalensis in a region of high human Lassa virus (LASV) seropositivity in Guinea. Standardized rodent trapping with similar trapping efforts between seasons was performed in three villages and 53.5% (601/1123) of the animals were identified as M. natalensis using morphometric and molecular criteria. Mean trapping success (TS) of M. natalensis was always higher inside houses than in proximal cultivations. In the dry season, mean TS increased 2-fold inside houses and decreased up to 10-fold outside (p < 0.0001), suggesting aggregation of rodents inside houses due to restricted food supply. 14.5% (80/553) of M. natalensis were tested positive for Lassa virus by reverse transcription-polymerase chain reaction (RT-PCR; range, 5%-30%) and prevalence of the virus was two to three times higher in rodents captured in the rainy season than in the dry season (p < 0.05). Inside houses, however the LASV prevalence fluctuated nonsignificantly with season. These data suggest that in Guinea the risk of LASV transmission from rodents to humans is present both in the rainy and the dry season, reflected by the occurrence of LF cases throughout the year. In the dry season, however, the increased risk of humans encountering Mastomys and their excreta inside of houses may result in an increase of human Lassa fever cases. © Mary Ann Liebert, Inc.
Authors & Co-Authors
Fichet-Calvet, Elisabeth
France, Paris
Museum National D'histoire Naturelle
Lecompte, Émilie
Germany, Marburg
Philipps-universität Marburg
Koivogui, Lamine
Guinea
Centre Hospitalier Donka
Soropogui, Barré
Guinea
Centre Hospitalier Donka
Doré, Amadou
Guinea
Centre Hospitalier Donka
Kourouma, Fodé
Guinea
Centre Hospitalier Donka
Sylla, Oumar
Guinea
Centre Hospitalier Donka
Daffis, Stéphane
Germany, Marburg
Philipps-universität Marburg
Koulémou, Kékoura
Guinea
Centre Hospitalier Donka
Ter Meulen, Jan H.
Germany, Marburg
Philipps-universität Marburg
Guinea
Centre Hospitalier Donka
Statistics
Citations: 117
Authors: 10
Affiliations: 3
Identifiers
Doi:
10.1089/vbz.2006.0520
ISSN:
15303667
Research Areas
Food Security
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative
Study Locations
Multi-countries
Guinea