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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Interleukin-2 before antiretroviral therapy in patients with HIV infection: A randomized trial (ANRS 119)
Journal of Infectious Diseases, Volume 200, No. 2, Year 2009
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Description
Background. Interleukin (IL)-2 increases CD4 T cell counts when combined with antiretroviral therapy (ART). Whether IL-2 alone can increase CD4 cell counts is unknown. Methods. A total of 130 adults who had a CD4 cell count of 300-500 cells/μL (and, thus, were not eligible to receive ART) were randomized to receive either intermittent IL-2 therapy or no treatment. The primary end point was a drop in CD4 cell count to <300 cells/μL, initiation of ART, the occurrence of an AIDS-defining event, or death. Results. Through week 96, 35% of the patients in the IL-2 arm and 59% in the control arm reached the primary end point (P = .008). Median changes from baseline in the IL-2 and control arms were +51 and -64 cells/μL, respectively, for CD4 cell count (P<.001) and were +0.02 and +0.04 log 10 copies/mL, respectively, for plasma viral load (P = .93). Among patients with a baseline viral load <4.5 log 10 copies/mL, 64% in the IL-2 arm and 10% in the control arm did not reach the primary end point through week 150 (P<.001), and the time to ART initiation was deferred by 92 weeks in the IL-2 arm. The incidences of an AIDS-defining event, death, and grade 3 or 4 adverse events were similar between study arms. Conclusion. IL-2 increased CD4 cell counts without affecting HIV replication and allowed the initiation of ART to be deferred. Trial registration. ClinicalTrials.gov identifier: NCT00120185. © 2009 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Molina, Jean Michel
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
France, Paris
Université Paris Cité
France, Paris
Hôpital Saint-louis
Lévy, Yvés
France, Paris
Inserm
France, Creteil
Université Paris-est Créteil Val de Marne
Fournier, Isabelle
France, Paris
Inserm
Bentata, Michelle
France, Bobigny
Hopital Avicenne
Gougeon, Marie Lise
France, Paris
Institut Pasteur, Paris
Venet, Alain
France, Paris
Inserm
France, Gif-sur-yvette
Université Paris-saclay
Madelaine, Isabelle F.
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
France, Paris
Université Paris Cité
Boulet, Thomas
France, Paris
Inserm
Simon, Franćois
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
France, Paris
Université Paris Cité
Aboulker, Jean Pierre
France, Paris
Inserm
Statistics
Citations: 20
Authors: 10
Affiliations: 10
Identifiers
Doi:
10.1086/599989
ISSN:
00221899
Research Areas
Infectious Diseases