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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Risk factors for Kaposi's sarcoma among HIV-positive individuals in a case control study in Cameroon
Cancer Epidemiology, Volume 38, No. 2, Year 2014
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Description
Background: Individuals co-infected with Kaposi's sarcoma herpesvirus (KSHV) and Human Immunodeficiency Virus (HIV) are at greatly increased risk of developing Kaposi's sarcoma (KS). The objective of the current analysis is to identify risk cofactors for KS among HIV-positive individuals. Methods: We conducted a case-control study of KS in Cameroon on 161 HIV-positive and 14 HIV-negative cases and 680 HIV-positive and 322 HIV-negative controls. Participants answered a physician-administered questionnaire and provided blood and saliva specimens. Antibodies against KSHV lytic, K8.1, and latent, ORF73, antigens were measured by ELISA to determine KSHV serostatus. Conditional logistic regression was performed to determine multivariate odds ratios (OR) and 95% confidence intervals (CI) for risk factors associated with KS among HIV-positive cases and controls. Results: Overall, 98% (158) of HIV-positive cases, 100% (14) of HIV-negative cases, 81% (550) of HIV-positive controls, and 80% (257) of HIV-negative controls were KSHV seropositive. Risk factors for KS among HIV-positive individuals included KSHV seropositivity (OR. = 9.6; 95% CI 2.9, 31.5), non-use of a mosquito bed net (OR 1.9; 95% CI 1.2, 2.9), minority ethnicity (OR. = 3.1; 95% CI 1.1, 9.3), treatment from a traditional healer (OR. = 2.3; 95% CI 1.5, 3.7), history of transfusion (OR. = 2.4; 95% CI 1.5, 3.9), and family history of cancer (OR. = 1.9; 95% CI 1.1, 3.1). Conclusion: KSHV seroprevalence of ≥80% indicates a high prevalence in the general population in Cameroon. Among HIV-positive individuals, the strong association of KS with non-use of mosquito nets and treatment from traditional healers are compelling findings, consistent with recently reported data from East Africa. © 2014 Elsevier Ltd.
Authors & Co-Authors
Stolka, Kristen B.
United States, Research Triangle Park
Rti International
Ndom, Paul
Cameroon, Yaounde
Sochimio
Hemingway-Foday, Jennifer J.
United States, Research Triangle Park
Rti International
Iriondo-Perez, Jeniffer
United States, Research Triangle Park
Rti International
Miley, Wendell J.
United States, Reston
Leidos Inc.
Labò, Nazzarena
United States, Reston
Leidos Inc.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Stella, Jennifer
United States, San Francisco
University of California, San Francisco
Abassora, Mahamat
Cameroon
Expanded Program on Immunization
Woelk, Godfrey B.
Cameroon
Expanded Program on Immunization
United States, Washington, D.c.
Elizabeth Glaser Pediatric Aids Foundation
Ryder, Robin
United States, La Jolla
University of California, San Diego
Whitby, Denise
United States, Reston
Leidos Inc.
Smith, Jennifer Susan
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Statistics
Citations: 38
Authors: 12
Affiliations: 9
Identifiers
Doi:
10.1016/j.canep.2014.02.006
ISSN:
18777821
e-ISSN:
1877783X
Research Areas
Cancer
Infectious Diseases
Study Design
Cross Sectional Study
Case-Control Study
Study Locations
Multi-countries
Cameroon