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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Full breastfeeding protection against common enteric bacteria and viruses: Results from the MAL-ED cohort study
American Journal of Clinical Nutrition, Volume 115, No. 3, Year 2022
Notification
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Description
Background: Breastfeeding is known to reduce the risk of enteropathogen infections, but protection from specific enteropathogens is not well characterized. Objective: The aim was to estimate the association between full breastfeeding (days fed breast milk exclusively or with nonnutritive liquids) and enteropathogen detection. Methods: A total of 2145 newborns were enrolled at 8 sites, of whom 1712 had breastfeeding and key enteropathogen data through 6 mo. We focused on 11 enteropathogens: adenovirus 40/41, norovirus, sapovirus, astrovirus, and rotavirus, enterotoxigenic Escherichia coli (ETEC), Campylobacter spp., and typical enteropathogenic E. coli as well as entero-aggregative E. coli, Shigella and Cryptosporidium. Logistic regression was used to estimate the risk of enteropathogen detection in stools and survival analysis was used to estimate the timing of first detection of an enteropathogen. Results: Infants with 10% more days of full breastfeeding within the preceding 30 d of a stool sample were less likely to have the 3 E. coli and Campylobacter spp. detected in their stool (mean odds: 0.92-0.99) but equally likely (0.99-1.02) to have the viral pathogens detected in their stool. A 10% longer period of full breastfeeding from birth was associated with later first detection of the 3 E. coli, Campylobacter, adenovirus, astrovirus, and rotavirus (mean HRs of 0.52-0.75). The hazards declined and point estimates were not statistically significant at 3 mo. Conclusions: In this large multicenter cohort study, full breastfeeding was associated with lower likelihood of detecting 4 important enteric pathogens in the first 6 mo of life. These results also show that full breastfeeding is related to delays in the first detection of some bacterial and viral pathogens in the stool. As several of these pathogens are risk factors for poor growth during childhood, this work underscores the importance of exclusive or full breastfeeding during the first 6 mo of life to optimize early health. © 2021 The Author(s). Published by Oxford University Press on behalf of the American Society for Nutrition.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC8895209/bin/nqab391_supplemental_file.docx
Authors & Co-Authors
McCormick, Benjamin J.J.
United States, Bethesda
National Institutes of Health Nih
Richard, Stephanie A.
United States, Bethesda
National Institutes of Health Nih
Murray-Kolb, Laura E.
United States, University Park
Pennsylvania State University
Kang, Gangandeep
India, Vellore
Christian Medical College, Vellore
Moreira Lima, Aldo Ângelo
Brazil, Fortaleza
Universidade Federal do Ceará
Mduma, Estomih R.
Tanzania, Mbulu
Haydom Lutheran Hospital
Kosek, Margaret N.
United States, Charlottesville
University of Virginia
Norway, Bergen
Universitetet I Bergen
Rogawski McQuade, Elizabeth T.
United States, Charlottesville
University of Virginia
Houpt, Eric R.
United States, Charlottesville
University of Virginia
Bessong, Pascal Obong
South Africa, Thohoyandou
University of Venda
Shrestha, Sanjaya K.
Nepal, Kathmandu
Walter Reed/afrims Research Unit
Bhutta, Zulfiqar A.
Pakistan, Karachi
The Aga Khan University
Ahmed, Tahmeed
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Caulfield, Laura E.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Acosta, Angel Mendez
Peru, Lima
Asociacion Benefica Prisma Lima
de Burga, Rosa Rios
Peru, Lima
Asociacion Benefica Prisma Lima
Chávez, Cesar Banda
Peru, Lima
Asociacion Benefica Prisma Lima
Flores, Julian Torres
Peru, Lima
Asociacion Benefica Prisma Lima
Olotegui, Maribel Paredes
Peru, Lima
Asociacion Benefica Prisma Lima
Pinedo, Silvia Rengifo
Peru, Lima
Asociacion Benefica Prisma Lima
Salas, Mery Siguas
Peru, Lima
Asociacion Benefica Prisma Lima
Trigoso, Dixner Rengifo
Peru, Lima
Asociacion Benefica Prisma Lima
Vasquez, Angel Orbe
Peru, Lima
Asociacion Benefica Prisma Lima
Ahmed, Imran
Pakistan, Karachi
The Aga Khan University
Alam, Didar
Pakistan, Karachi
The Aga Khan University
Ali, Asad S.
Pakistan, Karachi
The Aga Khan University
Bhutta, Zulfiqar A.
Pakistan, Karachi
The Aga Khan University
Qureshi, Shahida Mumtaz
Pakistan, Karachi
The Aga Khan University
Rasheed, Muneera Abdul
Pakistan, Karachi
The Aga Khan University
Soofi, Sajid Bashir
Pakistan, Karachi
The Aga Khan University
Turab, Ali
Pakistan, Karachi
The Aga Khan University
Yousafzai, Aisha Khizar
Pakistan, Karachi
The Aga Khan University
Zaidi, Anita Kaniz Mehdi
Unknown Affiliation
Bodhidatta, Ladaporn
Thailand, Bangkok
Armed Forces Research Institute of Medical Sciences, Thailand
Ammu, Geetha
India, Vellore
Christian Medical College, Vellore
Babji, Sudhir
India, Vellore
Christian Medical College, Vellore
Bose, Anuradha
India, Vellore
Christian Medical College, Vellore
George, Ajila T.
India, Vellore
Christian Medical College, Vellore
Hariraju, Dinesh
India, Vellore
Christian Medical College, Vellore
Jennifer, Mats Steffi
India, Vellore
Christian Medical College, Vellore
John, Sushil Mathew
India, Vellore
Christian Medical College, Vellore
Kaki, Shiny
India, Vellore
Christian Medical College, Vellore
Karunakaran, Priyadarshani
India, Vellore
Christian Medical College, Vellore
Koshy, Beena
India, Vellore
Christian Medical College, Vellore
Lazarus, Robin Penugula
India, Vellore
Christian Medical College, Vellore
Muliyil, Jayaprakash
India, Vellore
Christian Medical College, Vellore
Ragasudha, Preethi N.
India, Vellore
Christian Medical College, Vellore
Mohan, Venkata Raghava
India, Vellore
Christian Medical College, Vellore
Raju, Sophy
India, Vellore
Christian Medical College, Vellore
Ramachandran, Anup
India, Vellore
Christian Medical College, Vellore
Ramadas, Rakhi
India, Vellore
Christian Medical College, Vellore
Ramanujam, Karthikeyan
India, Vellore
Christian Medical College, Vellore
Rose, Anuradha R.
India, Vellore
Christian Medical College, Vellore
Roshan, Reeba
India, Vellore
Christian Medical College, Vellore
Sharma, Srujan Lam
India, Vellore
Christian Medical College, Vellore
Shanmuga Sundaram, E.
India, Vellore
Christian Medical College, Vellore
Thomas, Rahul Jacob
India, Vellore
Christian Medical College, Vellore
Pan, William K.Y.
United States, Durham
Duke University
Ambikapathi, Ramya
United States, West Lafayette
Purdue University
Carreon, Joseph Daniel
United States, Bethesda
National Institutes of Health Nih
Doan, Viyada
United States, Bethesda
National Institutes of Health Nih
Hoest, Christel
United States, Bethesda
National Institutes of Health Nih
Knobler, Stacey L.
United States, Bethesda
National Institutes of Health Nih
McGrath, Monica
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Miller, Mark A.
United States, Bethesda
National Institutes of Health Nih
Psaki, Stephanie R.
United States, Bethesda
National Institutes of Health Nih
United States, Washington
Congressional Hunger Center
Rasmussen, Zeba A.
United States, Bethesda
National Institutes of Health Nih
Seidman, Jessica C.
United States, Bethesda
National Institutes of Health Nih
Gottlieb, Michael
United States, Bethesda
National Institutes of Health Nih
Lang, Dennis R.
United States, Bethesda
National Institutes of Health Nih
Tountas, Karen H.
United States, Bethesda
National Institutes of Health Nih
Svensen, Erling
Norway, Bergen
Haukeland Universitetssjukehus
Amour, Caroline
Tanzania, Mbulu
Haydom Lutheran Hospital
Bayyo, Eliwaza B.
Tanzania, Mbulu
Haydom Lutheran Hospital
Mduma, Estomih R.
Tanzania, Mbulu
Haydom Lutheran Hospital
Mvungi, Regisiana
Tanzania, Mbulu
Haydom Lutheran Hospital
Nshama, Rosemary P.
Tanzania, Mbulu
Haydom Lutheran Hospital
Pascal, John
Tanzania, Mbulu
Haydom Lutheran Hospital
Swema, Buliga Mujaga
Tanzania, Mbulu
Haydom Lutheran Hospital
Yarrot, Ladislaus Blacy
Tanzania, Mbulu
Haydom Lutheran Hospital
Mason, Carl J.
United States, Rockville
Hjf
Shamsir Ahmed, Abul Mansur
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Alam, Md Ashraful
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Haque, Rashidul
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Haque, Umma
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Hossain, Md Iqbal
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Islam, Mohammad Munirul
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Mahfuz, Mustafa U.
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Mondal, Dinesh K.
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Nahar, Baitun
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Tofail, Fahmida
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Chandyo, Ram Krishna
Nepal, Kathmandu
Kathmandu Medical College
Shrestha, Prakash Sunder
Nepal, Kathmandu
Tribhuvan University
Shrestha, Rita
Nepal, Kathmandu
Tribhuvan University
Ulak, Manjeswori
Nepal, Kathmandu
Tribhuvan University
Bauck, Aubrey
United States, Washington
Congressional Hunger Center
Black, Robert E.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Checkley, William N.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Lee, Gwenyth O.Neill
United States, Ann Arbor
University of Michigan School of Public Health
Schulze, Kerry J.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Peñataro Yori, Pablo
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Ross, A. Catharine
United States, University Park
Pennsylvania State University
Schaefer, Barbara A.
United States, University Park
Pennsylvania State University
Simons, Suzanne
United States, University Park
Pennsylvania State University
Pendergast, Laura L.
United States, Philadelphia
Temple University
Abreu, Claúdia B.
Brazil, Fortaleza
Universidade Federal do Ceará
Costa, Hilda
Brazil, Fortaleza
Universidade Federal do Ceará
Moura, Alessandra Di
Brazil, Fortaleza
Universidade Federal do Ceará
Filho, José Quirino S.
Brazil, Fortaleza
Universidade Federal do Ceará
Havt, Alexandre
Brazil, Fortaleza
Universidade Federal do Ceará
Leite, Álvaro Jorge Madeiro
Brazil, Fortaleza
Universidade Federal do Ceará
Lima, Noélia Leal
Brazil, Fortaleza
Universidade Federal do Ceará
Lima, Ila Fernanda Nunes
Brazil, Fortaleza
Universidade Federal do Ceará
MacIel, Bruna Leal Lima
Brazil, Fortaleza
Universidade Federal do Ceará
Medeiros, Pedro Henrique Quintela Soares
Brazil, Fortaleza
Universidade Federal do Ceará
Moraes, Milena L.
Brazil, Fortaleza
Universidade Federal do Ceará
Mota, Francisco Suetônio Bastos
Brazil, Fortaleza
Universidade Federal do Ceará
Quetz, Josiane S.
Brazil, Fortaleza
Universidade Federal do Ceará
Soares, Alberto Melo
Brazil, Fortaleza
Universidade Federal do Ceará
Mota, Rosa Maria Salani
Brazil, Fortaleza
Universidade Federal do Ceará
Patil, Crystal L.
United States, Chicago
University of Illinois at Chicago
Mahopo, Cloupas
South Africa, Thohoyandou
University of Venda
Maphula, Angelina
South Africa, Thohoyandou
University of Venda
Nyathi, Emanuel
South Africa, Thohoyandou
University of Venda
Samie, Amidou
South Africa, Thohoyandou
University of Venda
Barrett, Leah J.
United States, Charlottesville
University of Virginia
Dillingham, Rebecca Anne
United States, Charlottesville
University of Virginia
Gratz, Jean C.
United States, Charlottesville
University of Virginia
Guerrant, Richard Littleton
United States, Charlottesville
University of Virginia
Houpt, Eric R.
United States, Charlottesville
University of Virginia
Petri, William Arthur J.
United States, Charlottesville
University of Virginia
Platts-Mills, James A.
United States, Charlottesville
University of Virginia
Scharf, Rebecca J.
United States, Charlottesville
University of Virginia
Shrestha, Binob
Nepal, Kathmandu
Walter Reed/afrims Research Unit
Rayamajhi, Bishnu Bahadur
Nepal, Kathmandu
Walter Reed/afrims Research Unit
Shrestha, Sanjaya Kumar
Nepal, Kathmandu
Walter Reed/afrims Research Unit
Strand, Tor A.
Norway, Bergen
Universitetet I Bergen
Statistics
Citations: 10
Authors: 137
Affiliations: 24
Identifiers
Doi:
10.1093/ajcn/nqab391
ISSN:
00029165
Research Areas
Food Security
Maternal And Child Health
Study Design
Cohort Study
Study Approach
Quantitative