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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
The Effect of Reducing the Exposure Time of Mitomycin C in Glaucoma Filtering Surgery
Ophthalmology, Volume 102, No. 1, Year 1995
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Description
Background: The use of adjunctive intraoperative mitomycin C has considerably improved the success rate of glaucoma filtering surgery. However, the ideal concentration and exposure time of mitomycin C is unknown. The purpose of this study is to determine whether a satisfactory surgical outcome can be achieved with a lower incidence of adverse side effects by using a shorter exposure time of mitomycin C than has been recommended previously. Methods: Twenty-five eyes of 25 consecutive patients who were considered to be at high risk for surgical failure because of their age (<55 years), previous failure of trabeculectomy, previous cataract surgery, or traumatic glaucoma received a single intraoperative application of mitomycin C (0.2 mg/ml for 2 minutes). They were casematched with a group of 48 consecutive patients who received a single intraoperative application of mitomycin C (0.2 mg/ml for 5 minutes) by using age, race, type of refractory glaucoma, and preoperative intraocular pressure (IOP) as variables. Results: Eighteen months after surgery, 22 (88%) patients in the 2-minute group and 21 (84%) patients in the 5-minute group had an IOP less than 21 mmHg with or without treatment. No significant differences were found in the complication rate: in 2 (8%) of 25 eyes of the 2-minute group, chronic hypotony developed compared with 3 (12%) of 25 eyes in the 5-minute group. Hypotony-related maculopathy developed in one eye in the 5-minute group. A cystic bleb was found in 15 (60%)eyes in the 2-minute group compared with 19 (76%) eyes in the 5-minute group, although this difference was not statistically significant. Two (8%)eyes in the 2-minute group and one eye (4%) in the 5-minute group had a bleb-related infection. In one (4%) patient in each group, late severe endophthalmitis developed. Conclusion: These results suggest that a 2-minute intraoperative application of 0.2 mg/ml mitomycin C is as effective as a 5-minute exposure, but the complication rate remains unaltered. © 1995, American Academy of Ophthalmology, Inc. All rights reserved.
Authors & Co-Authors
Mégevand, Gordana Sunaric
South Africa, Observatory
Groote Schuur Hospital
Salmon, John F.
South Africa, Observatory
Groote Schuur Hospital
Scholtz, Raoul P.
South Africa, Observatory
Groote Schuur Hospital
Murray, Anthony David Neil
South Africa, Observatory
Groote Schuur Hospital
Statistics
Citations: 156
Authors: 4
Affiliations: 1
Identifiers
Doi:
10.1016/S0161-6420(95)31049-4
Research Areas
Health System And Policy
Study Design
Cohort Study