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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
A single immunization with a recombinant canine adenovirus type 2 expressing the seoul virus Gn glycoprotein confers protective immunity against seoul virus in mice
Vaccine, Volume 27, No. 38, Year 2009
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Description
Seoul virus (SEOV), a member of hantavirus genus, is one of the causative agents of hemorrhagic fever with renal syndrome (HFRS) and afflicts tens of thousands of people annually. In this paper, we evaluate the immune response induced by a replication-competent recombinant canine adenovirus type 2 expressing the Gn protein of SEOV (rCAV-2-Gn) in BALB/c mice. Sera from immunized mice contained neutralizing antibodies that could specifically recognize SEOV and neutralize its infectivity in vitro. Moreover, the recombinant virus induced complete protection against a lethal challenge with the highly virulent SEOV strain CC-2. Protective level neutralizing antibodies were maintained for at least 20 weeks. The efficacy of the recombinant was similar to that induced by a currently available inactivated HFRS vaccine. This recombinant virus is therefore a potential alternative to the inactivated vaccine. Crown Copyright © 2009.
Authors & Co-Authors
Yuan, Ziguo
China, Guangzhou
South China Agricultural University
China, Beijing
Academy of Military Sciences
Li, Xiu Ming
China, Daqing
Heilongjiang August First Reclamation University
Mahmmod, Yasser
Egypt, Zagazig
Faculty of Veterinary Medicine
Wang, Xiaohu
China, Beijing
Academy of Military Sciences
Xu, Hui Juan
China, Guangzhou
Guangzhou Institute of Biomedicine and Health
Zhang, Xiuxiang
China, Guangzhou
South China Agricultural University
China, Changchun
College of Plant Science
Statistics
Citations: 13
Authors: 6
Affiliations: 6
Identifiers
Doi:
10.1016/j.vaccine.2009.06.062
ISSN:
0264410X
Research Areas
Maternal And Child Health