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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Mortality of HIV-1, HIV-2 and HIV-1/HIV-2 dually infected patients in a clinic-based cohort in The Gambia
AIDS, Volume 16, No. 13, Year 2002
Notification
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Description
Objective: To assess and compare the mortality rates of patients with HIV-1, HIV-2 or both infections (HIV-D) in the same population. Design: Clinic-based cohort study. Methods: HIV-seropositive patients aged 15 years and older who attended the Medical Research Council clinics in Fajara between May 1986 and September 1997 were recruited. Clinical assessment using the Karnofsky score, CDC cell staging, WHO staging, and CD4 cell counts was performed at baseline. Patients attended clinic every 3 months; if they did not attend, they were visited at home by field workers to ascertain survival status. No patient was on antiretroviral therapy during the study period. Results: Data from 1519 HIV-positive adult patients were analysed. A total of 746 patients had HIV-1, 666 HIV-2, and 107 patients had HIV-D. A total of 828 patients (55%) died, and 161 (11%) were lost to follow-up. The median follow-up was 12 months (range 0-128). CD4 cell counts were available for 894 patients. Compared with HIV-1, the adjusted hazards ratio for mortality in the CD4 cell count category 500 cells/μl or greater was 0.50 for HIV-2 (95% CI 0.28-0.88) and 1.27 (95% CI 0.51-3.7) for HIV-D. Among those with CD4 cell counts less than 500 cells/μl the mortality rates in HIV-2 and HIV-D were similar to those in HIV-1. Discussion: HIV-2-infected patients with CD4 cell counts of 500 cells/μl and greater had a significantly lower mortality rate than HIV-1-infected patients. HIV-2-infected patients with advanced disease had the same poor prognosis as patients with HIV-1. Dually infected patients had mortality rates similar to HIV-1. © 2002 Lippincott Williams & Wilkins.
Authors & Co-Authors
Schim-van der Loeff, Maarten Franciscus
United Kingdom, London
London School of Hygiene & Tropical Medicine
Jaffar, Shabbar S.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Aveika, Akum Akum
United Kingdom, London
London School of Hygiene & Tropical Medicine
Sabally, Saihou
United Kingdom, London
London School of Hygiene & Tropical Medicine
Corrah, Tumani P.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Harding, Elizabeth
United Kingdom, London
London School of Hygiene & Tropical Medicine
Alabi, Abraham Sunday
United Kingdom, London
London School of Hygiene & Tropical Medicine
Ariyoshi, Koya
United Kingdom, London
London School of Hygiene & Tropical Medicine
Whittle, Hilton C.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Statistics
Citations: 93
Authors: 9
Affiliations: 1
Identifiers
Doi:
10.1097/00002030-200209060-00010
ISSN:
02699370
Research Areas
Health System And Policy
Infectious Diseases
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative
Study Locations
Gambia